公开(公告)号：EP0705606B1

公开(公告)日：1998-03-18

申请号：EP95114673.7

申请日：1995-09-18

申请人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo

发明人： Kovacevic, Mice, D. Sc. ,  Grdisa, Mira, D. Sc. ,  Pavelic, Kresimir, D. Sc. ,  Horvatic, Marjeta, M. Sc. ,  Mandic, Zora M. Sc. ,  Tomic, Mirjana M. Sc. ,  Herak, Jure J., D. Sc. ,  Lukic, Irena, M. Sc.

IPC分类号： A61K31/54

CPC分类号： A61K31/549

公开(公告)号：EP0705606A1

公开(公告)日：1996-04-10

申请号：EP95114673.7

申请日：1995-09-18

申请人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo

发明人： Kovacevic, Mice, D. Sc. ,  Grdisa, Mira, D. Sc. ,  Pavelic, Kresimir, D. Sc. ,  Horvatic, Marjeta, M. Sc. ,  Mandic, Zora M. Sc. ,  Tomic, Mirjana M. Sc. ,  Herak, Jure J., D. Sc. ,  Lukic, Irena, M. Sc.

IPC分类号： A61K31/54

CPC分类号： A61K31/549

摘要： The present invention relates to the use of 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo compounds of the general formula I,

wherein the radicals have the following meanings:

R¹ is hydrogen, halogen,
R² is hydrogen, halogen, amino, PhCH₂CONH, PhOCH₂CONH, phthalimido, o-MeNHCOC₆H₄CONH, 3-o-chlorophenyl-5-methyl-isoxazolyl-4-carbonyl amino,
R³ is hydrogen, alkyl, benzyl, a heterocyclic ring e.g. isoxazole, pyrazole,
n is 1 or 2.

In the application examples of the suppression of uterine cervix carcinoma cells (HeLa) by the use of various substituted 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo derivatives are disclosed.

摘要翻译： 本发明涉及通式I的“5-硫杂-1,4-二氮杂双环[2,4.2,0]辛烷-3,8-二氧代化合物的用途，其中基团具有以下含义：R 1是氢 卤素，R 2是氢，卤素，氨基，PhCH 2 CONH，PhOCH 2 CONH，苯二甲酰亚氨基，o-MeNHCOC 6 H 4 CONH，3-邻氯苯基-5-甲基 - 异恶唑基-4-羰基氨基，R 3是氢，烷基， 苄基，杂环例如 异恶唑，吡唑，n为1或2.在通过使用各种取代的5-硫杂-1,4-二氮杂双环[2,4.2,0]辛烷-3,8-二氧代衍生物抑制子宫颈癌细胞（HeLa）的应用实施例中 被披露。