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1.发明公开1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF 有权1-氧杂-3-氮杂 - 二苯并如肿瘤坏死因子的产生为他们产生抑制剂和中间产品
公开(公告)号：EP1492797A1
公开(公告)日：2005-01-05
申请号：EP03745848.6
申请日：2003-04-09
发明人： MERCEP, Mladen , MESIC, Milan , PESIC, Dijana , BENKO, Iva
IPC分类号： C07D498/04 , A61K31/42
CPC分类号： C07D263/52 , Y02P20/55
摘要： The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
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2.发明公开THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权THIADIBENZOAZULENDERIVATE炎症性疾病的治疗
公开(公告)号：EP1603921A1
公开(公告)日：2005-12-14
申请号：EP04717708.4
申请日：2004-03-05
发明人： MERCEP, Mladen , MESIC,Milan , PESIC, Dijana , BENKO, Iva
IPC分类号： C07D495/04 , A61K31/382 , A61P29/00
CPC分类号： C07D495/04
摘要： The present invention relates to novel 1-thia-dibenzoazulene derivatives of the formula (I), wherein X individually denotes a hetero atom -O- or -S-; Y and Z independently from each other individually denote a fragment of the formula (II) to their pharmacologically acceptable esters, salts and solvates, to processes and intermediates for the preparation thereof, to a process for preparing pharmaceutical formulations for the treatment of inflammatory diseases and conditions and to the use thereof in the treatment of inflammatory diseases and conditions in humans and animals. These compounds inhibit tumour necrosis factor-α(TNF-(α) production and interleukin-1 (IL-1) production and exhibit an analgetic action.
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3.发明授权1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF 有权1-氧杂-3-氮杂 - 二苯并如肿瘤坏死因子的产生为他们产生抑制剂和中间产品
公开(公告)号：EP1492797B1
公开(公告)日：2006-03-15
申请号：EP03745848.6
申请日：2003-04-09
发明人： MERCEP, Mladen , MESIC, Milan , PESIC, Dijana , BENKO, Iva
IPC分类号： C07D498/04 , A61K31/42
CPC分类号： C07D263/52 , Y02P20/55
摘要： The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
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