Cloning of honey bee allergen C
    2.
    发明公开
    Cloning of honey bee allergen C 有权
    Klonierung des Bienen-Allergens C

    公开(公告)号:EP1873165A1

    公开(公告)日:2008-01-02

    申请号:EP06013165.3

    申请日:2006-06-26

    申请人: PLS-Design GmbH

    CPC分类号: C07K14/43572 C12N9/6402

    摘要: The present invention relates to a nucleic acid encoding a polypeptide capable of binding to IgE from subjects allergic to venom of an insect from the order Hymenoptera having a homology of more than 70% to the amino acid sequence of SEQ ID NO: 2, which is the honey bee allergen C (Api m 5). The invention further relates to expression vectors, host cells and polypeptides encoded by the nucleic acid, as well as diagnostic and pharmaceutical uses thereof.

    摘要翻译: 本发明涉及一种编码能够从与来自SEQ ID NO:2的氨基酸序列具有多于70%同源性的膜翅目昆虫的毒液过敏的受试者的能够结合IgE的多肽的核酸,其是SEQ ID NO: 蜂蜜过敏原C(Api m 5)。 本发明还涉及由核酸编码的表达载体,宿主细胞和多肽,以及其诊断和药物用途。