-
1.发明公开Process for the preparation of delta(15-16)-17-ketosteroids and use thereof in the synthesis of pharmacologically active compounds 有权一种生产德尔塔（15,16）-17-酮基类固醇以及它们在药理学活性的化合物的合成过程中使用
公开(公告)号：EP1586579A1
公开(公告)日：2005-10-19
申请号：EP05101435.5
申请日：2005-02-25
摘要： A process is described for the preparation of Δ 15-16 -17-ketosteroids of the formula
in which the substituents have the meaning stated in the description, which process comprises a) the reaction of a 17-ketosteroid of the formula
with diphenyl disulfide in the presence of a strong base, b) the subsequent oxidation reaction of the intermediate 16-phenyl sulfide to the sulfoxide and c) the sulfoxide elimination reaction to yield the Δ 15-16 ―17-ketosteroid compound of the formula (6). Said process is preferably applied to the synthesis of gestodene.摘要翻译： 方法描述用于制备DELTA式
在其中取代基具有的含义在说明书陈述的<15-16> -17酮基类固醇的方法，其包括A）的一个17-酮类固醇的反应 式在强碱的存在下 使用二苯基二硫化物，b）将中间体16 - 苯基硫醚的后续氧化反应成亚砜和c）亚砜消除反应，得到DELTA <15-16> -17- 式酮类固醇化合物（6）。 所述方法优选应用于孕激素的合成。 -
2.发明授权A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase 失效为的17-β-羧基取代-3-氧代-4- azasteroids改造和使用此类产品的作为酶5-α-还原酶的抑制剂微生物法
公开(公告)号：EP0922770B1
公开(公告)日：2002-09-18
申请号：EP98124126.8
申请日：1995-10-10
CPC分类号： C07J73/005 , C12P33/02
-
3.发明公开A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase 失效用于转化17β-羧基取代的3-氧代-4-氮杂甾体的微生物学方法以及作为酶抑制剂的5α-还原酶
公开(公告)号：EP0922770A3
公开(公告)日：1999-06-30
申请号：EP98124126.8
申请日：1995-10-10
IPC分类号： C12P33/06
CPC分类号： C07J73/005 , C12P33/02
摘要： The present invention relates to a microbiological process for the transformation of 17β-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5α-reductase.
摘要翻译： 本发明涉及用于转化17β-取代的4-氮杂雄甾烷-3-酮的微生物学方法以及生物转化产物作为酶5α-还原酶的抑制剂的用途。
-
4.发明公开A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase 失效为的17-β-羧基取代-3-氧代-4- azasteroids改造和使用此类产品的作为酶5-α-还原酶的抑制剂微生物法
公开(公告)号：EP0922770A2
公开(公告)日：1999-06-16
申请号：EP98124126.8
申请日：1995-10-10
IPC分类号： C12P33/06
CPC分类号： C07J73/005 , C12P33/02
摘要： The present invention relates to a microbiological process for the transformation of 17β-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5α-reductase.
摘要翻译： 本发明涉及一种微生物处理为17的β转变取代4- azaandrostan -3-酮和使用生物转化产品的作为酶5α还原酶的抑制剂。
-
-
-
搜索结果
4 条记录 (耗时 0.011 秒)
