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1.发明公开
公开(公告)号：EP2906178A4
公开(公告)日：2016-08-10
申请号：EP13845090
申请日：2013-10-11
发明人： MCHALE WILLIAM A , BROWN DALE G
CPC分类号： A61Q11/00 , A61K8/062 , A61K8/21 , A61K8/23 , A61K8/362 , A61K8/365 , A61K8/891 , A61K8/90 , A61K9/006 , A61K9/0063 , A61K9/107 , A61K2800/31
摘要： Improved remineralizing and desensitizing compositions containing remineralizing ingredients in aqueous-free emulsions that, in the presence of saliva, form mucoadhesive gels substantive to tooth surfaces; wherein the gels are dissolved by saliva gradually releasing remineralizing ingredients onto tooth surfaces, treatments with these compositions and methods of manufacture.
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公开(公告)号：EP2890385A4
公开(公告)日：2016-03-23
申请号：EP13845305
申请日：2013-10-10
发明人： MCHALE WILLIAM A , BROWN DALE G
IPC分类号： A61K31/59 , A61K9/00 , A61K31/05 , A61K31/09 , A61K31/592 , A61K31/593 , A61K36/28 , A61K47/34 , A61P1/02
摘要： A topical vitamin D and UBIQUINOL supplement composition useful in treating oral inflammation and reducing oxidative stress comprising: a supplement mixture of vitamin D and UBIQUINOL in an aqueous-free emulsion containing: spilanthes extract, stabilizing compositions for UBIQUINOL and trans-oral mucosal absorption facilitators for the supplement mixture; where the emulsion forms a mucoadhesive gel in the presence of saliva, that effects passive diffusion through the oral mucosa of the supplement mixture and spilanthes extract regulating: in vivo availability and immune response of the supplement mixture, and maintaining adequate levels of circulating vitamin D and of adjunctively administered UBIQUINOL, while minimizing the risk of hypercalcemia.
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公开(公告)号：EP2887945A4
公开(公告)日：2016-03-23
申请号：EP13844920
申请日：2013-10-10
发明人： MCHALE WILLIAM A , BROWN DALE G
IPC分类号： A61K31/59 , A61K9/00 , A61K9/10 , A61K9/107 , A61K31/592 , A61K31/593 , A61K47/10 , A61P1/02 , A61P31/00
CPC分类号： A61K31/592 , A61K9/006 , A61K9/06 , A61K31/593 , A61K47/10
摘要： Topical, vitamin D, oral supplement compositions useful in treating oral inflammation comprising vitamin D in an aqueous-free emulsion containing a trans-oral mucosal absorption facilitator, where said emulsion forms a mucoadhesive coating in the presence of saliva; wherein saliva dissolution of the mucoadhesive gel releases vitamin D and the trans-oral mucosal, absorption facilitator; effecting: vitamin D passive diffusion; regulating in vivo availability and immune response of vitamin D; and maintaining adequate levels of circulating vitamin D while minimizing the risk of hypercalcemia.
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公开(公告)号：EP3129000A4
公开(公告)日：2017-11-29
申请号：EP15777496
申请日：2015-04-10
发明人： MCHALE WILLIAM A , BROWN DALE G
摘要： Substantially aqueous-free, enamel protectant and enamel repair toothpastes containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpastes indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
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公开(公告)号：EP3128999A4
公开(公告)日：2017-11-22
申请号：EP15776096
申请日：2015-04-10
发明人： MCHALE WILLIAM A , BROWN DALE G
摘要： A method of treatment for enamel with substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
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6.发明公开TOPICAL UBIQUINOL ORAL SUPPLEMENT COMPOSITIONS WITH AMORPHOUS CALCIUM PHOSPHATE 审中-公开TOPISCHE UBIQUINOL-NAHRUNGSERGÄNZUNGSMITTELZUSAMMENSETZUNGENMIT AMORPHEM CALCIUMPHOSPHAT
公开(公告)号：EP2906179A4
公开(公告)日：2016-07-06
申请号：EP13845393
申请日：2013-10-11
发明人： MCHALE WILLIAM A , BROWN DALE G
IPC分类号： A61K31/59 , A61K9/00 , A61K31/05 , A61K31/09 , A61K31/592 , A61K31/593 , A61K33/42 , A61K36/28 , A61K47/34 , A61P1/02
CPC分类号： A61K31/09 , A61K8/345 , A61K8/891 , A61K9/0014 , A61K9/006 , A61K9/0063 , A61K31/122 , A61K33/42 , A61K47/10 , A61Q11/00 , A61K2300/00
摘要： Topical, UBIQUINOL, adjunctive, supplement compositions, containing amorphous calcium phosphate fluoride (ACPF), useful in: reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing hydroxyapatite; comprising: UBIQUINOL in an aqueous-free emulsion that also contains: a stabilizing composition for UBIQUINOL, spilanthes extract, a trans-oral mucosal, absorption facilitator and ACPF; wherein: the emulsion forms a mucoadhesive gel in the presence of saliva that undergoes gradual saliva dissolution effecting passive diffusion of the UBIQUINOL supplement and the spilanthes extract into the oral mucosa, and remineralizing of tooth surfaces with ACPF; resulting in: adjunctively increasing UBIQUINOL levels, reducing oxidative stress, regulating immune response, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces.
摘要翻译： 含有无定形磷酸钙氟化物（ACPF）的局部，UBIQUINOL，辅料，补充剂组合物，用于：减少氧化应激，缓解口腔不适和口干，以及再矿化羟基磷灰石; 其包含：UBIQUINOL在无水乳液中，其还含有：UBIQUINOL，spillanthes提取物，经口粘膜，吸收促进剂和ACPF的稳定组合物; 其中：所述乳液在存在唾液的情况下形成粘膜粘附性凝胶，所述唾液经历逐渐的唾液溶解，从而影响UBIQUINOL补充剂和稀释剂提取物被动扩散到口腔粘膜中，并且用ACPF重新矿化牙齿表面; 导致：辅助增加UBIQUINOL水平，减少氧化应激，调节免疫反应，缓解口腔不适和口干，并使牙齿表面再矿化。
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