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公开(公告)号：EP1196083B1
公开(公告)日：2008-03-19
申请号：EP00944946.3
申请日：2000-06-28
CPC分类号： A61K51/0497 , A61K51/0448
摘要： A method of diagnosing attention deficient-hyperactivity disorder (AD-HD) in a human patient by assessing dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of AD-HD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to dopamine transporter using PET or SPECT.
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公开(公告)号：EP1196083A1
公开(公告)日：2002-04-17
申请号：EP00944946.3
申请日：2000-06-28
IPC分类号： A61B5/00
CPC分类号： A61K51/0497 , A61K51/0448
摘要： A method of diagnosing attention deficient-hyperactivity disorder (AD-HD) in a human patient by assessing dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of AD-HD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to dopamine transporter using PET or SPECT.
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公开(公告)号：EP1725269B1
公开(公告)日：2012-12-26
申请号：EP05714006.3
申请日：2005-02-24
IPC分类号： A61K51/04 , C07D241/04
CPC分类号： A61K51/04 , A61B6/507 , A61B6/508 , C07B59/00 , C07B2200/05 , C07D241/04
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公开(公告)号：EP1725269A1
公开(公告)日：2006-11-29
申请号：EP05714006.3
申请日：2005-02-24
IPC分类号： A61K51/00
CPC分类号： A61K51/04 , A61B6/507 , A61B6/508 , C07B59/00 , C07B2200/05 , C07D241/04
摘要： One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium sait. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.
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公开(公告)号：EP1436429A2
公开(公告)日：2004-07-14
申请号：EP02797755.2
申请日：2002-08-26
CPC分类号： A61K51/0491 , A61K38/00 , A61K47/51 , A61K51/04 , C12N15/113 , C12N15/1135 , C12N2310/315 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517
摘要： The invention provides targeted constructs comprising a targeting moiety, a nucleic acid, and payload. The payload can be a detectable label or a therapeutic agent. The nucleic acid can be an antisense molecule that is complementary to RNA present in a target cell. The targeted constructs can be used to introduce the payload into a target cell in vivo or in vitro. Accordingly, the invention can be used for diagnostic purposes and for therapeutic purposes.
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6.发明授权Polybiotin compounds for magnetic resonance imaging and drug delivery 有权Polybiotinverbindungen用于磁共振成像和用于药物递送
公开(公告)号：EP1684810B1
公开(公告)日：2013-09-25
申请号：EP04793906.1
申请日：2004-10-01
IPC分类号： A61K51/00 , A61B5/055 , A61K47/48 , A61K51/04 , A61K49/10 , A61K49/08 , A61K51/08 , C07D519/00 , A61P35/00 , A61P29/00 , A61P31/00
CPC分类号： C07D519/00 , A61B5/0059 , A61B5/055 , A61B5/412 , A61B5/4839 , A61K47/557 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/124 , A61K51/0446 , A61K51/0497 , G01R33/5601
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7.发明公开POLYBIOTIN COMPOUNDS FOR MAGNETIC RESONANCE IMAGINING AND DRUG DELIVERY 有权Polybiotinverbindungen用于磁共振成像和用于药物递送
公开(公告)号：EP1684810A1
公开(公告)日：2006-08-02
申请号：EP04793906.1
申请日：2004-10-01
CPC分类号： C07D519/00 , A61B5/0059 , A61B5/055 , A61B5/412 , A61B5/4839 , A61K47/557 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/124 , A61K51/0446 , A61K51/0497 , G01R33/5601
摘要： The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.
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8.发明公开
公开(公告)号：EP1011738A1
公开(公告)日：2000-06-28
申请号：EP98945939.1
申请日：1998-09-08
CPC分类号： A61K51/0491 , A61K51/088
摘要： The invention provides imaging agents comprising a label in association with a plaque specific targeting molecule. Methods for using the imaging agents to diagnose or monitor plaque formation and growth and kits containing the cardiovascular agents or components suitable for production of the imaging agents are also provided.
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