公开(公告)号：EP0646119A1

公开(公告)日：1995-04-05

申请号：EP93914197.0

申请日：1993-05-27

申请人： PROCTER & GAMBLE PHARMACEUTICALS, INC.

发明人： EBETINO, Frank, Hallock ,  KAAS, Susan, Mary ,  FRANCIS, Marion, David ,  NELSON, Dennis, George, Anthony ,  JANUSZ, John, Michael

IPC分类号： A61K31 ,  A61P1 ,  A61P19 ,  A61P29 ,  A61P43 ,  C07F9

CPC分类号： C07F9/582 ,  C07F9/3873 ,  C07F9/5722 ,  C07F9/5765 ,  C07F9/592 ,  C07F9/65062

摘要： The present invention relates to quaternary nitrogen-containing phosphonate compounds, and the pharmaceutically-acceptable salts and esters thereof and having general structure (I). The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism such as osteoporosis, rheumatoid arthritis, and osteoarthritis in humans or other mammals and to methods for treating or preventing dental calculus, plaque and gingivitis. This method comprises administering to a human or other mammal in need of such treatment a safe and effective amount of a compound or composition of the present invention.