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1.发明公开THE USE OF PERIPHERAL OPIOIS ANTAGONISTS, ESPECIALLY METHYLNALTREXONE TO TREAT IRRITABLE BOWEL SYNDROME 审中-公开使用PERIPHERERN阿片受体拮抗剂，尤其是对肠易激综合症的治疗甲基纳曲酮
公开(公告)号：EP1617846A1
公开(公告)日：2006-01-25
申请号：EP04759348.8
申请日：2004-04-08
IPC分类号： A61K31/485 , A61P1/00
CPC分类号： A61K45/06 , A61K9/0031 , A61K9/02 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K9/2846 , A61K9/2866 , A61K31/00 , A61K31/485 , A61K31/765 , A61K2300/00
摘要： Methods of treating irritable bowel syndrome with peripheral opioid antagonists, such as methylnaltrexone, are provided. Formulations comprising peripheral opioid antagonists, such as methylnaltrexone, and irritable bowel syndrome therapeutic agents are also provided.
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公开(公告)号：EP1615646A1
公开(公告)日：2006-01-18
申请号：EP04759349.6
申请日：2004-04-08
IPC分类号： A61K31/485
CPC分类号： A61K47/02 , A61K9/0019 , A61K9/19 , A61K31/047 , A61K31/195 , A61K31/485 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/183 , A61K2300/00
摘要： Stable pharmaceutical compositions useful for administering methylnaltrexone are described, as are methods for making the same. Kits, including these pharmaceutical compositions, also are provided.
摘要翻译： 描述了可用于施用甲基纳曲酮的稳定的药物组合物，以及制备它们的方法。 还提供了包括这些药物组合物的试剂盒。
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3.发明授权(S)-N-METHYLNALTREXONE, PROCESS FOR ITS SYNTHESIS AND ITS PHARMACEUTICAL USE 有权（S） - N - 甲，用于生产及其药物用途
公开(公告)号：EP1928882B1
公开(公告)日：2013-09-04
申请号：EP06771162.2
申请日：2006-05-25
发明人： WAGONER, Howard , SANGHVI, Suketu, P. , BOYD, Thomas, A. , VERBICKY, Christopher , ANDRUSKI, Stephen
IPC分类号： C07D489/08 , A61K31/485 , A61P1/12 , A61P25/04
CPC分类号： C07D489/08
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4.发明公开COMBINATION THERAPY FOR CONSTIPATION COMPRISING A LAXATIVE AND A PERIPHERAL OPIOID ANTAGONIST 审中-公开综合疗法具有通便和外围阿片受体拮抗剂便秘
公开(公告)号：EP1638607A1
公开(公告)日：2006-03-29
申请号：EP04759350.4
申请日：2004-04-08
IPC分类号： A61K45/06 , A61K31/485 , A61P1/10
CPC分类号： A61K9/2846 , A61K9/0031 , A61K9/02 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Methods for treating constipation are provided. The methods include administration of peripheral opioid antagonists in combination with laxatives and/or stool softeners. Patients treatable by the invention include those refractory to conventional laxative and stool softener therapy.
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公开(公告)号：EP1615646B1
公开(公告)日：2014-12-24
申请号：EP04759349.6
申请日：2004-04-08
IPC分类号： A61K9/08 , A61K45/06 , A61K47/12 , A61K47/18 , A61K9/19 , A61K31/047 , A61K31/195 , A61K31/485
CPC分类号： A61K47/02 , A61K9/0019 , A61K9/19 , A61K31/047 , A61K31/195 , A61K31/485 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/183 , A61K2300/00
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6.发明公开(S)-N-METHYLNALTREXONE, PROCESS FOR ITS SYNTHESIS AND ITS PHARMACEUTICAL USE 有权（S） - N - 甲，用于生产及其药物用途
公开(公告)号：EP1928882A2
公开(公告)日：2008-06-11
申请号：EP06771162.2
申请日：2006-05-25
发明人： WAGONER, Howard , SANGHVI, Suketu, P. , BOYD, Thomas, A. , VERBICKY, Christopher , ANDRUSKI, Stephen
IPC分类号： C07D489/08 , A61K31/485 , A61P1/12 , A61P25/04
CPC分类号： C07D489/08
摘要： This invention relates to S-MNTX, methods of producing S-MNTX, pharmaceutical preparations comprising S-MNTX and methods for their use.
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公开(公告)号：EP1282416A2
公开(公告)日：2003-02-12
申请号：EP00986812.6
申请日：2000-10-20
IPC分类号： A61K31/375 , A61K47/02 , A61K47/12 , A01N1/02
CPC分类号： A61K9/0014 , A61K31/375 , A61K45/06 , A61K47/02 , A61K47/12 , A61K2300/00
摘要： The invention provides improved dehydroascorbic acid compositions and methods for treatment of medical conditions. The dehydroascorbic acid compositions are useful in the treatment of a variety of conditions which benefit from increased dehydroascorbic acid or ascorbic acid concentrations in tissues affected by the conditions.
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