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公开(公告)号：EP0915832B1
公开(公告)日：2002-10-02
申请号：EP97935178.0
申请日：1997-07-24
申请人： PROLINX, INC.
IPC分类号： C07C233/49 , G01N33/53 , C07C259/10 , C07F5/02
CPC分类号： C07C237/22 , C07C229/38 , C07C233/49 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , G01N33/54353
摘要： Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula (CIII), General formula (CIV), and General Formula (CVI). In one embodiment, the reagents of General formula (CIII) may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula (CIV). The reagent of General Formula (CIV) may be used to form a complex with a boron compound, such as a complex shown in General Formula (CVI).
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公开(公告)号：EP0920413B1
公开(公告)日：2002-11-13
申请号：EP97934313.4
申请日：1997-07-24
申请人： PROLINX, INC. , SYSTEMIX, INC.
IPC分类号： C07C237/12 , C07C233/13 , C07C233/09 , C07C259/10 , C07D207/40 , C07D207/44 , C07D213/71 , C07F5/02 , G01N33/543
CPC分类号： C07D207/452 , C07C233/51 , C07C237/12 , C07C259/10 , C07D207/46 , C07D213/71 , C07F5/025
摘要： Boron compound complexing reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula (III), General Formula (IV), and General Formula (VI). In one embodiment, the reagents of General Formula (III) may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula (IV). The reagent of General Formula (IV) may be used to form a complex with a boron compound, such as a complex shown in General Formula (VI).
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3.发明公开
公开(公告)号：EP1240355A1
公开(公告)日：2002-09-18
申请号：EP00970699.5
申请日：2000-10-06
申请人： PROLINX, INC.
发明人： SPICER, Douglas, A. , HUGHES, Karin, A. , KAISER, Robert, J. , MAHONEY, James, E. , SPRINGER, Amy, L. , STOLOWITZ, Mark, L. , WEISSMAN, Carl, H. D.
CPC分类号： C12Q1/6869 , C12Q1/6844 , C12Q2563/107 , C12Q2563/149 , C12Q2565/137
摘要： This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the unincorporated dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.
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4.发明公开NOVEL BORONIC ACID-CONTAINING NUCLEIC ACIDS AND THEIR USE AS DIAGNOSTIC AGENTS 失效新BORSA您含有核酸和它们作为诊断试剂
公开(公告)号：EP0923591A1
公开(公告)日：1999-06-23
申请号：EP97935061.0
申请日：1997-07-31
申请人： PROLINX, INC.
摘要： Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide base in a position which does not interfere with the hydrogen bonding capabilities of that base during duplex formation. The modified polynucleotides are typically formed from naturally occurring nucleotides and one or more modified nucleotides.
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公开(公告)号：EP0920413A1
公开(公告)日：1999-06-09
申请号：EP97934313.0
申请日：1997-07-24
申请人： PROLINX, INC. , SYSTEMIX, INC.
CPC分类号： C07D207/452 , C07C233/51 , C07C237/12 , C07C259/10 , C07D207/46 , C07D213/71 , C07F5/025
摘要： Boron compound complexing reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula (III), General Formula (IV), and General Formula (VI). In one embodiment, the reagents of General Formula (III) may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula (IV). The reagent of General Formula (IV) may be used to form a complex with a boron compound, such as a complex shown in General Formula (VI).
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公开(公告)号：EP1165569A1
公开(公告)日：2002-01-02
申请号：EP00916555.6
申请日：2000-03-17
申请人： PROLINX, INC.
CPC分类号： C12N15/113 , C07F9/6596 , C07H21/00 , C12N2310/318 , C12N2310/33
摘要： The present invention provides arylboronic acid reagents useful for incorporation into modified oligonucleotides and polynucleotides. The modified oligonucleotides and polynucleotides thus produced are useful in bioconjugation reactions for the immobilization and purification of macromolecules.
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公开(公告)号：EP0915832A1
公开(公告)日：1999-05-19
申请号：EP97935178.0
申请日：1997-07-24
申请人： PROLINX, INC.
IPC分类号： G01N33 , B01J20 , C07C229 , C07C233 , C07C237 , C07C247 , C07C255 , C07C259 , C07C271 , C07C281 , C07D207 , C07F5 , C12N15 , C12Q1 , G01N30
CPC分类号： C07C237/22 , C07C229/38 , C07C233/49 , C07C255/13 , C07C259/10 , C07C271/22 , C07C281/02 , G01N33/54353
摘要： Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula (CIII), General formula (CIV), and General Formula (CVI). In one embodiment, the reagents of General formula (CIII) may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula (CIV). The reagent of General Formula (CIV) may be used to form a complex with a boron compound, such as a complex shown in General Formula (CVI).
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