公开(公告)号：EP0808167A4

公开(公告)日：1998-06-10

申请号：EP96903815

申请日：1996-02-09

申请人： PURDUE RESEARCH FOUNDATION ,  METHODIST HEALTH GROUP INC

发明人： BADYLAK STEPHEN F ,  VOYTIK SHERRY

IPC分类号： A61L27/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61K35/38 ,  A61L27/36

CPC分类号： A61L27/3683 ,  A61F2/28 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61K35/38 ,  A61L27/3629 ,  A61L27/365 ,  A61L2430/02

摘要： A method for repairing damaged or diseased bone is described. The method comprises the step of implanting into the damaged or diseased region a bone graft composition in powder form, the composition comprising the tunica submucosa delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa of a segment of vertebrate intestine.

公开(公告)号：EP0809691A4

公开(公告)日：2000-06-21

申请号：EP96905458

申请日：1996-02-09

申请人： PURDUE RESEARCH FOUNDATION ,  METHODIST HEALTH GROUP INC ,  LILLY CO ELI

发明人： BADYLAK STEPHEN F ,  BODER GEORGE ,  VOYTIK SHERRY ,  DEMETER ROBERT J ,  CRITSER JOHN K ,  LIU CHI

IPC分类号： C12M3/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  A61K35/37 ,  A61K35/38

CPC分类号： C12N5/0655 ,  C12M23/34 ,  C12M25/02 ,  C12N5/0068 ,  C12N5/0676 ,  C12N5/0679 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2533/92 ,  Y10S623/915

摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.