专利检索 ap:("Pacific Northwest Cancer Foundation") AND inv:"TINO, William, T." 第 1 页

1.

发明公开
MONOCLONAL ANTIBODIES SPECIFIC FOR THE EXTRACELLULAR DOMAIN OF PROSTATE SPECIFIC MEMBRANE ANTIGEN 无效
标题翻译：特异性单克隆抗体PROTASTA特异性膜抗原的胞外域

公开(公告)号：EP0914155A1

公开(公告)日：1999-05-12

申请号：EP97917121.0

申请日：1997-03-25

申请人： Pacific Northwest Cancer Foundation

发明人： MURPHY, Gerald, P. , BOYNTON, Alton, L. , HOLMES, Eric, H. , TINO, William, T.

IPC分类号： G01N33 , A61K39 , A61K45 , A61K51 , A61P13 , A61P35 , C07K16 , C12N5 , C12N15 , A61K38

CPC分类号： C07K16/28 , A61K38/00 , C07K2317/34 , C12N2799/026

摘要： The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, it relates to three monoclonal antibodies reactive with PSMA expressed on the cell surface and in sera of prostate cancer patients. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by an antibody of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.