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    Method of female contraception and kit for use in such method
    1.
    发明公开
    Method of female contraception and kit for use in such method 有权
    女性避孕和药物制剂，其适用于这样的方法

    公开(公告)号：EP1462107A1

    公开(公告)日：2004-09-29

    申请号：EP03075905.4

    申请日：2003-03-28

    申请人： Pantarhei Bioscience B.V.

    发明人： Coelingh Bennink, Herman Jan Tijmen ,  Visser, Monique

    IPC分类号： A61K31/565 ,  A61K31/57 ,  A61P15/18

    CPC分类号： A61K31/565 ,  A61K31/57 ,  A61K2300/00

    摘要： The present invention is concerned with a method of contraception in a female mammal of childbearing capability, said method comprising orally administering to the female a combination of estrogen and progestogen continuously for at least 3 months, wherein the estrogen is selected from the group consisting of 17β-estradiol, precursors of 17β-estradiol and combinations thereof, said estrogen being administered in an amount equivalent to a daily oral dosage of 2.2-5 mg 17β-estradiol and said progestogen being administered in an amount equivalent to a daily oral dose of 5-50 mg dydrogesterone.
    Another aspect of the invention relates to a kit comprising a plurality of oral dosage units, said plurality of daily hormone units containing an estrogen in an amount equivalent to 2.2-5 mg 17β-estradiol and a progestogen in an amount equivalent to 5-50 mg dydrogesterone, wherein the estrogen is selected from the group consisting of 17β-estradiol, precursors of 17β-estradiol and combinations thereof.

    摘要翻译： 本发明是在一个雌性哺乳动物生育能力的关注避孕的方法，是选自下组的17选择的所述方法包括口服给予所述女性的雌激素和孕激素的组合连续至少3个月，worin雌激素 β-雌二醇，17β-雌二醇以及它们的组合的前体，所述雌激素给药在等效量的2.2-5毫克17β-雌二醇和孕激素的每日口服剂量，所述被以相等的量施用到每日口服剂量 的5-50毫克地屈孕酮。 本发明的另一个方面涉及一种试剂盒，包括口服剂量单位的复数，在相当量的雌激素的含至2.2-5毫克17β-雌二醇每天激素单元的所述多个并在等效量的孕激素 到5-50毫克地屈孕酮，worin雌激素选自17β-雌二醇的，17β-雌二醇以及它们的组合的前体中选择。

    Pharmaceutical compositions and kits comprising 17-beta-estradiol and a progesteron for the treatment of gynecological disorders
    2.
    发明公开
    Pharmaceutical compositions and kits comprising 17-beta-estradiol and a progesteron for the treatment of gynecological disorders 审中-公开
    Pharmazeutishe组合物和试剂盒含有的17 Betaestradiol和孕酮用于病症Gynäcologischen治疗

    公开(公告)号：EP1462106A1

    公开(公告)日：2004-09-29

    申请号：EP03075904.7

    申请日：2003-03-28

    申请人： Pantarhei Bioscience B.V.

    发明人： Coelingh Bennink, Herman Jan Tijmen ,  Visser, Monique

    IPC分类号： A61K31/565 ,  A61K31/57 ,  A61P15/00

    CPC分类号： A61K31/565 ,  A61K31/57 ,  A61K2300/00

    摘要： The present invention is concerned with a method of treating or preventing an estrogen sensitive gynaecological disorder in a female mammal, said method comprising administering to the female a combination of estrogen and progestogen continuously for at least 3 months, wherein the estrogen is selected from the group consisting of 17β-estradiol, precursors of 17β-estradiol and combinations thereof, said estrogen being administered in an amount equivalent to a daily oral dosage of 2.2-5 mg 17β-estradiol and said progestogen being administered in an amount equivalent to a daily oral dose of 5-50 mg dydrogesterone.
    Another aspect of the invention relates to a kit comprising a plurality of oral dosage units, said plurality of daily hormone units containing an estrogen in an amount equivalent to 2.2-5 mg 17β-estradiol and a progestogen in an amount equivalent to 5-50 mg dydrogesterone, wherein the estrogen is selected from the group consisting of 17β-estradiol, precursors of 17β-estradiol and combinations thereof.

    摘要翻译： 本发明涉及治疗或雌性哺乳动物的雌激素敏感的妇科病症的预防，所述方法包括给予所述女性的雌激素和孕激素的组合连续至少3个月，worin雌激素的方法选自 由17β-雌二醇的，17β-雌二醇以及它们的组合的前体，所述雌激素给药在等效量的2.2-5毫克17β-雌二醇和孕激素的每日口服剂量在等当量的所述给药在一个 每日口服剂量的5-50毫克地屈孕酮的。 本发明的另一个方面涉及一种试剂盒，包括口服剂量单位的复数，在相当量的雌激素的含至2.2-5毫克17β-雌二醇每天激素单元的所述多个并在等效量的孕激素 到5-50毫克地屈孕酮，worin雌激素选自17β-雌二醇的，17β-雌二醇以及它们的组合的前体中选择。