公开(公告)号：EP1534716B1

公开(公告)日：2008-04-23

申请号：EP03763818.6

申请日：2003-07-11

申请人： Pfizer Italia S.r.l.

发明人： TONANI, Roberto ,  BINDI, Simona ,  FANCELLI, Daniele ,  PITTALA', Valeria ,  D'ANELLO, Matteo

IPC分类号： C07D495/04 ,  C07D491/04 ,  C07D471/04 ,  C07D333/38 ,  C07D307/68 ,  C07D333/42 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D307/68 ,  C07D333/38 ,  C07D333/42 ,  C07D491/04 ,  C07D495/04

摘要： Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

公开(公告)号：EP1530573B1

公开(公告)日：2008-03-19

申请号：EP03766152.7

申请日：2003-07-11

申请人： Pfizer Italia S.r.l.

发明人： TONANI, Roberto ,  BINDI, Simona ,  FANCELLI, Daniele ,  PITTALA', Valeria ,  VARASI, Mario

IPC分类号： C07D495/04 ,  A61K31/4162

CPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.