公开(公告)号：EP1178115A3

公开(公告)日：2002-08-07

申请号：EP01305392.1

申请日：2001-06-21

申请人： Pfizer Limited ,  PFIZER INC.

发明人： Parums, Dinah, C/o Pfizer Limited, The EPD ,  Phillipps, Stefen Charles, Pfizer Global Res.& Dev ,  Ridden, John, C/o Pfizer Limited, The EPD

IPC分类号： C12N15/55 ,  C12N9/16 ,  C07K16/40 ,  C12Q1/44 ,  A61K39/395 ,  A61K38/46 ,  A61K31/70

CPC分类号： G01N33/6893 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/16 ,  C12Q1/44

摘要： The present invention relates to an isolated target sequence. The target sequence is a splice variant of PDE5 called a PDE5a1, a component of which is presented as SEQ ID No 1. The identified target sequence of the present invention may be used to as a target to identify agents (such as modulators) useful in the prevention and/or treatment of a disease associated with scarring and/or fibrosis or to selectively identify smooth muscle cells and myofibroblasts and myoepithelial cells in samples of normal and diseased tissue from individuals.