公开(公告)号：EP2146779B1

公开(公告)日：2016-08-10

申请号：EP08719431.2

申请日：2008-04-07

申请人： Pfizer Products Inc.

发明人： LUZZIO, Michael, Joseph ,  AUTRY, Christopher, Lowell ,  BHATTACHARYA, Samit, Kumar ,  FREEMAN-COOK, Kevin, Daniel ,  HAYWARD, Matthew, Merrill ,  HULFORD, Catherine Angela ,  NELSON, Kendra, Louise ,  XIAO, Jun ,  ZHAO, Xumiao

IPC分类号： A61P35/00 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/506 ,  A61K31/53

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D241/20 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D475/00

摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：EP2146779A1

公开(公告)日：2010-01-27

申请号：EP08719431.2

申请日：2008-04-07

申请人： Pfizer Products Inc.

发明人： LUZZIO, Michael, Joseph ,  AUTRY, Christopher, Lowell ,  BHATTACHARYA, Samit, Kumar ,  FREEMAN-COOK, Kevin, Daniel ,  HAYWARD, Matthew, Merrill ,  HULFORD, Catherine Angela ,  NELSON, Kendra, Louise ,  XIAO, Jun ,  ZHAO, Xumiao

IPC分类号： A61P35/00 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/506 ,  A61K31/53

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D241/20 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D475/00

摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

公开(公告)号：EP1966207A2

公开(公告)日：2008-09-10

申请号：EP06831737.9

申请日：2006-12-11

申请人： Pfizer Products Inc.

发明人： ARCARI, Joel, Thomas ,  BHATTACHARYA, Samit, Kumar ,  BROSIUS, Arthur, Douglas ,  LUZZIO, Michael, Joseph ,  NELSON, Kendra, Louise ,  PAN, Gonghua ,  SOUTHERS, James, Alfred, Jr. ,  WISHKA, Donn, Gregory ,  XIAO, Jun

IPC分类号： C07D471/08 ,  C07D487/08 ,  C07D495/08 ,  C07D519/00 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D471/08 ,  C07D487/08 ,  C07D495/08

摘要： The present invention relates to a compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a group of Formula (II) and salts thereof. Such pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.