公开(公告)号：EP1461306B1

公开(公告)日：2008-12-24

申请号：EP02793840.6

申请日：2002-10-25

申请人： Pharmacia & Upjohn Company LLC

发明人： RICHARDS, Ivan ,  CAMMARATA, Sue, K. ,  WEGNER, Craig, D. ,  HAWLEY, Michael ,  WARCHOL, Mark, P. ,  KONTNY, Mark ,  MOROZOWICH, Walter ,  KOLBASA, Karen, P. ,  MOON, Malcolm, W. ,  BONAFOUX, Dominique ,  WOLFSON, Sergey, G. ,  LENNON, Patrick, J.

IPC分类号： C07C211/27 ,  C07C211/29 ,  C07C215/54 ,  C07C215/66 ,  C07C219/28 ,  C07D295/02 ,  C07C217/62 ,  A61K31/14 ,  A61K31/452 ,  A61K31/40 ,  A61P11/00

CPC分类号： C07D295/096 ,  C07C215/54 ,  C07C215/66 ,  C07C217/62 ,  C07C219/28 ,  C07C237/30

摘要： Novel quaternary ammonium compounds of the formula (I) and any stereoisomers thereof, wherein, R1, R2, and R3 independently represent C1-C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 and R3 may form a ring together with the quaternary ammonium nitrogen; R4 represents -H, -CH3, or -CO-R4-1, wherein R4-1 represents -(C1-C4 alkyl), -(C1-C4 alkoxy), or NR4-2R4-3, wherein R4-2 and R4-3 independently represent -H or -(C1-C4 alkyl); R5, R6 and R7 independently represent -H, -OCH3, -OH, -CONH2, -SO2NH2, -F, -Cl, -Br, -I, -CF3, or -(C1-C4 alkyl), optionally substituted with one or two -OH, -(C1-C4 alkoxy), -COOH, or -CO-O-(C1-C3 alkyl); and X represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.