专利检索 ap:("Pharmacia Corporation") AND inv:"DURLEY, Richard" 第 1 页

1.

发明公开
PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS 审中-公开
标题翻译：嘧啶-4-酮衍生物及其作为P38激酶调节剂

公开(公告)号：EP1753731A2

公开(公告)日：2007-02-21

申请号：EP04724083.3

申请日：2004-03-29

申请人： Pharmacia Corporation

发明人： DURLEY, Richard , DEVADAS, Balekudru , MADSEN, Heather , HICKORY, Brian , PALMQUIST, Katherine , SELNESS, Shaun

IPC分类号： C07D239/52 , C07D239/46 , A61K31/513 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/12

CPC分类号： C07D239/47 , C07D239/52 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/12

摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.