专利检索 ap:("Pharmacia Corporation") AND inv:"KOTYK, John, J." 第 1 页

1.

发明公开
METHODS AND CONTRAST AGENTS USEFUL IN QUANTIFYING NITRIC OXIDE 审中-公开
标题翻译：方法和造影剂一氧化氮的测定

公开(公告)号：EP1525003A1

公开(公告)日：2005-04-27

申请号：EP03762236.2

申请日：2003-06-27

申请人： Pharmacia Corporation

发明人： JONES, Claude, R. , BASHKIN, James, K. , RADER, Randall, K. , KOTYK, John, J. , NEUMANN, William, L. , MISKO, Thomas, P. , KORNMEIER, Christine, M.

IPC分类号： A61K49/06

CPC分类号： A61K49/101 , A61K49/10 , A61K49/106

摘要： A contrast agent for nuclear magnetic resonance spectroscopy adapted for use in a living tissue comprising at least one reporter nucleus, together with a pharmaceutically acceptable carrier is disclosed. The contrast agent exhibits a first spectral property when not bound by nitric oxide, and a second spectral property when bound by nitric oxide. Methods of using the contrast agents for the detection of nitric oxide are also disclosed.