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1.发明公开SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 有权取代的多环芳基和HETEROARYLPYRAZINONE用于凝血级联的选择性抑制
公开(公告)号：EP1202975A1
公开(公告)日：2002-05-08
申请号：EP00931916.1
申请日：2000-05-18
发明人： SOUTH, Michael, S. , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , DICE, Tom , LINDMARK, Richard , HAYES, Michael, J. , RUEPPEL, Melvin, L. , FENTON, Rick , FRANKLIN, Gary, W. , HUANG, Horng-Chih , HUANG, Wei , KUSTURIN, Carrie , LONG, Scott, A. , NEUMANN, William, L. , REITZ, David B. , TRUJILLO, John, I. , WANG, Ching-Cheng , WOOD, Rhonda , MAHONEY, Matthew, W. , Zeng, Qingping
IPC分类号： C07D241/20 , C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D409/12 , A61K31/495 , A61K31/497 , A61P7/02
CPC分类号： C07D401/12 , C07D241/20 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
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2.发明授权SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 有权取代的多环芳基和HETEROARYLPYRAZINONE用于凝血级联的选择性抑制
公开(公告)号：EP1202975B1
公开(公告)日：2005-04-06
申请号：EP00931916.1
申请日：2000-05-18
发明人： SOUTH, Michael, S. , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , DICE, Tom , LINDMARK, Richard , HAYES, Michael, J. , RUEPPEL, Melvin, L. , FENTON, Rick , FRANKLIN, Gary, W. , HUANG, Horng-Chih , HUANG, Wei , KUSTURIN, Carrie , LONG, Scott, A. , NEUMANN, William, L. , REITZ, David B. , TRUJILLO, John, I. , WANG, Ching-Cheng , WOOD, Rhonda , MAHONEY, Matthew, W. , Zeng, Qingping
IPC分类号： C07D241/20 , C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D409/12 , A61K31/495 , A61K31/497 , A61P7/02
CPC分类号： C07D401/12 , C07D241/20 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
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