公开(公告)号：EP1572693A1

公开(公告)日：2005-09-14

申请号：EP03814268.3

申请日：2003-12-19

申请人： Pharmacia Corporation

发明人： ANDERSON, David, R. ,  MAHONEY, Matthew, W. ,  PHILLION, Dennis, P. ,  ROGERS, Thomas, E. ,  MEYERS, Marvin, J. ,  PODA, Gennadiy ,  HEGDE, Shridhar, G. ,  SINGH, Megh ,  REITZ, David, B. ,  WU, Kun, K. ,  BUCHLER, Ingrid, P. ,  XIE, Jin ,  VERNIER, William, F.

IPC分类号： C07D471/06

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D471/14 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

摘要： Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of using such compounds for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNFα, are described, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Therapeutic compositions, pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.