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1.发明公开
公开(公告)号：EP1345604A1
公开(公告)日：2003-09-24
申请号：EP01986259.8
申请日：2001-09-21
IPC分类号： A61K31/40 , C07D403/14
CPC分类号： A61K31/40
摘要： The present invention relates to an administration schedule comprising the intravenous administration of a α-halogen-acryloyl distamycin derivative, or a pharmaceutically acceptable salt thereof. The above administration allows the treatment of a variety of tumors in mammals.
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公开(公告)号：EP1430306A2
公开(公告)日：2004-06-23
申请号：EP02779404.9
申请日：2002-09-19
发明人： FOWST, Camilla , GERONI, Maria, Cristina, Rosa , TURSI, Jennifer, Margaret , VREELAND, Franzanne
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57488 , G01N2333/91171 , G01N2800/52
摘要： Herewith described is a novel method for predicting the sensitivity towards chemotherapy, of a patient in need thereof, which comprises obtaining a blood sample from the patient and detecting the levels of blood glutathione (GSH) as a surrogate marker for glutathione-S-transferase (GST) activity in tumor tissues.
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3.发明授权USE OF A ALPHA-HALOGEN-ACRYLOYL DISTAMYCIN DERIVATE FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF CANCER 有权ALPHA-haloacryloyl-偏端霉素衍生物用于制备药物用于癌症治疗中的用途
公开(公告)号：EP1345604B1
公开(公告)日：2006-09-13
申请号：EP01986259.8
申请日：2001-09-21
IPC分类号： A61K31/40 , C07D403/14 , A61P35/00
CPC分类号： A61K31/40
摘要： The present invention relates to an administration schedule comprising the intravenous administration of a alpha -halogen-acryloyl distamycin derivative, or a pharmaceutically acceptable salt thereof. The above administration allows the treatment of a variety of tumors in mammals.
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