公开(公告)号：EP1272489B1

公开(公告)日：2003-09-24

申请号：EP01936098.1

申请日：2001-03-19

申请人： Pharmacia Italia S.p.A. ,  Tomasi, Attilio ,  Magenes, Stefania ,  Ungari, Mario ,  Ramella, Giuliano ,  Pallanza, Gianfranco

发明人： TOMASI, Attilio ,  MAGENES, Stefania ,  UNGARI, Mario ,  RAMELLA, Giuliano ,  PALLANZA, Gianfranco

IPC分类号： C07D457/04

CPC分类号： C07D457/04

摘要： A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of cabergoline, useful as an intermediate, is also provided.

公开(公告)号：EP1272489A1

公开(公告)日：2003-01-08

申请号：EP01936098.1

申请日：2001-03-19

申请人： Pharmacia Italia S.p.A. ,  Tomasi, Attilio ,  Magenes, Stefania ,  Ungari, Mario ,  Ramella, Giuliano ,  Pallanza, Gianfranco

发明人： TOMASI, Attilio ,  MAGENES, Stefania ,  UNGARI, Mario ,  RAMELLA, Giuliano ,  PALLANZA, Gianfranco

IPC分类号： C07D457/04

CPC分类号： C07D457/04

摘要： A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of cabergoline, useful as an intermediate, is also provided.

公开(公告)号：EP1280803B1

公开(公告)日：2004-11-10

申请号：EP01915373.3

申请日：2001-03-19

申请人： Pharmacia Italia S.p.A.

发明人： TOMASI, Attilio ,  MAGENES, Stefania ,  RAMELLA, Giuliano ,  UNGARI, Mario ,  PANDOLFI, Marco

IPC分类号： C07D457/06

CPC分类号： C07D457/06

摘要： Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from a solution of raw cabergoline in an organic solvent at low temperatures or submitting to a slurry procedure a mixture of cabergoline Forms I and II in a solvent at a temperature below about 30 °C.

公开(公告)号：EP1280803A1

公开(公告)日：2003-02-05

申请号：EP01915373.3

申请日：2001-03-19

申请人： Pharmacia Italia S.p.A.

发明人： TOMASI, Attilio ,  MAGENES, Stefania ,  RAMELLA, Giuliano ,  UNGARI, Mario ,  PANDOLFI, Marco

IPC分类号： C07D457/06

CPC分类号： C07D457/06

摘要： Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from a solution of raw cabergoline in an organic solvent at low temperatures or submitting to a slurry procedure a mixture of cabergoline Forms I and II in a solvent at a temperature below about 30 °C.

公开(公告)号：EP1487840A1

公开(公告)日：2004-12-22

申请号：EP03743335.6

申请日：2003-02-26

申请人： Pharmacia Italia S.p.A.

发明人： FORINO, Romualdo ,  BARBUGIAN, Natale ,  ZAMPIERI, Massimo ,  TOMASI, Attilio

IPC分类号： C07D491/22 ,  A61K31/4375 ,  A61P35/00

CPC分类号： C07D491/22

摘要： This invention relates to a novel crystalline polymorphic form of irinotecan hydrochloride. A process for preparing this novel polymorphic form, pharmaceutical compositions comprising it as an active ingredient and the use of the same and its pharmaceutical compositions as a therapeutic agent is also within the scope of the present invention.

公开(公告)号：EP1485383A1

公开(公告)日：2004-12-15

申请号：EP03712002.9

申请日：2003-03-10

申请人： Pharmacia Corporation ,  Pharmacia Italia S.p.A.

发明人： SHEIKH, Ahmad, Y. ,  TOMASI, Attilio

IPC分类号： C07D457/06

CPC分类号： A61K31/42 ,  C07D261/08 ,  C07D457/06

摘要： A process for producing crystalline form I of cabergoline, which process comprises the preparation of Form V using heptane as precipitation solvent, and its exclusive conversion into crystalline Form I of cabergoline. The present crystallization process from toluene-heptane solvent system for form V involves 'reverse addition' of toluene-cabergoline concentrate to cold heptane.