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9 条记录 (耗时 0.011 秒)

    A STABLE IRON OLIGOSACCHARIDE COMPOUND
    1.
    发明公开
    A STABLE IRON OLIGOSACCHARIDE COMPOUND 有权
    稳定的铁寡糖CONNECTION

    公开(公告)号：EP2411053A1

    公开(公告)日：2012-02-01

    申请号：EP09776213.2

    申请日：2009-03-25

    申请人： Pharmacosmos Holding A/s

    发明人： ANDREASEN, Hans

    IPC分类号： A61K47/26 ,  A61K47/48

    CPC分类号： C08B37/0021 ,  A61K47/26 ,  C07H3/06

    摘要： The invention relates to an iron oligosaccharide compound with improved stability comprising a hydrogenated oligosaccharide in stable association with ferric oxyhydroxide, the content of dimer saccharide in said hydrogenated oligosaccharide being 2.9 % by weight or less, based on the total weight of the hydrogenated oligosaccharide. In further aspects is provided a process for preparing said compound as well as the use of said compound for preparation of a composition for treatment of iron deficiency anaemia.

    AN OLIGOSACCHARIDE AND A PROCESS FOR PREPARATION THEREOF
    2.
    发明公开
    AN OLIGOSACCHARIDE AND A PROCESS FOR PREPARATION THEREOF 审中-公开

    公开(公告)号：EP3821910A1

    公开(公告)日：2021-05-19

    申请号：EP20200455.2

    申请日：2009-03-25

    申请人： Pharmacosmos Holding A/s

    发明人： ANDREASEN, Hans

    IPC分类号： A61K47/26 ,  A61K47/50 ,  A61K9/00

    摘要： The invention relates to an oligosaccharide having a weight average molecular weight (Mw) of less than 3,000 Daltons, wherein said oligosaccharide comprises functional aldehyde groups and has a dimer saccharide content of 2.9 % by weight or less, based on the total weight of the hydrogenated oligosaccharide. The invention also relates to a process for preparing the oligosaccharide, which process comprises the steps of: hydrolysing a polysaccharide so as to reduce its molecular weight, wherein the resulting oligosaccharide comprises functional aldehyde groups, and fractioning the oligosaccharide according to molecular weight, so that the purified fraction has a weight average molecular weight equal to or less than 3,000 Daltons. The procedure of purification is performed by one or more membrane processes, having a cut-off value between 340 and 800 Daltons, which procedure is continued until the content of dimer saccharide in the purified fraction of oligosaccharide has been reduced to 2.9 % by weight or less, based on the total weight of the hydrogenated oligosaccharide.

    TREATMENT OR PREVENTION OF ANAEMIA IN PREGNANT NON-HUMAN MAMMALS
    6.
    发明公开
    TREATMENT OR PREVENTION OF ANAEMIA IN PREGNANT NON-HUMAN MAMMALS 审中-公开
    治疗或预防妊娠非人类哺乳动物的贫血

    公开(公告)号：EP3212182A1

    公开(公告)日：2017-09-06

    申请号：EP15787128.6

    申请日：2015-10-27

    申请人： Pharmacosmos Holding A/s

    发明人： RECKE, Christian von der ,  CHRISTENSEN, Tobias S. ,  ANDREASEN, Hans ,  THOMSEN, Lars Lykke

    IPC分类号： A61K31/295 ,  A61K31/721 ,  A61P7/06

    CPC分类号： A61K31/721 ,  A61K9/0019 ,  A61K31/295 ,  A61K47/10 ,  A61K2300/00

    摘要： The present invention relates to an iron carbohydrate complex for use in a method of increasing the blood haemoglobin concentration in a pregnant non-human mammal, wherein the pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less, is administered one or more doses of iron carbohydrate complex comprising an amount of elemental iron of 1800 mg or more per dose. The method relates to the further effects of decreasing the rate of stillborn offsprings from a pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less, increasing the blood haemoglobin concentration of offspring litters within 3 days from birth and/or weaning, or increasing the litter size in a subsequent parity of a non-human mammal having a blood haemoglobin level of 105 g/L or less.

    摘要翻译： 本发明涉及用于提高怀孕的非人类哺乳动物血液血红蛋白浓度的方法中的铁碳水化合物复合物，其中血液中血红蛋白水平为105g / L或更低的怀孕的非人类哺乳动物被施用 一个或多个剂量的铁碳水化合物复合物，其包含每剂量1800mg或更多的元素铁的量。 该方法涉及降低血红蛋白水平为105g / L或更低的怀孕非人类哺乳动物的死胎后代的进一步效果，增加后代产仔3天内血液血红蛋白浓度和/或 断奶或增加具有血红蛋白水平为105g / L或更低的非人哺乳动物的随后胎次的窝产仔数。

    IRON CARBOHYDRATE COMPLEX FOR TREATMENT OF RESTLESS LEG SYNDROME (RLS)
    7.
    发明公开
    IRON CARBOHYDRATE COMPLEX FOR TREATMENT OF RESTLESS LEG SYNDROME (RLS) 审中-公开
    用于治疗无症状腿综合征（RLS）的铁碳水化合物复合物

    公开(公告)号：EP3270935A1

    公开(公告)日：2018-01-24

    申请号：EP16713771.0

    申请日：2016-03-17

    申请人： Pharmacosmos Holding A/s

    发明人： THOMSEN, Lars Lykke ,  CHRISTENSEN, Tobias S. ,  ANDREASEN, Hans

    IPC分类号： A61K33/26 ,  A61P25/14

    CPC分类号： A61K33/26 ,  A61K47/61

    摘要： The present invention relates to pharmaceutical composition comprising an iron carbohydrate complex for use in a method for treatment or prevention of Restless Leg Syndrome (RLS) of a human patient, wherein the human patient prior to treatment has a magnetic resonance phase imaging of 0.02 radians above the average value of a control group in the substantia nigra, thalamus, putamen, or pallidum. The invention provides a higher probability for a RLS patient being treated to experience a relief in symptoms.

    AN OLIGOSACCHARIDE AND A PROCESS FOR PREPARATION THEREOF
    8.
    发明公开
    AN OLIGOSACCHARIDE AND A PROCESS FOR PREPARATION THEREOF 审中-公开
    VIGFAHREN ZUR HERSTELLUNG DAVON的OLIGOSACCHARID

    公开(公告)号：EP3156075A1

    公开(公告)日：2017-04-19

    申请号：EP16201189.4

    申请日：2009-03-25

    申请人： Pharmacosmos Holding A/S

    发明人： ANDREASEN, Hans

    IPC分类号： A61K47/26 ,  A61K47/50

    CPC分类号： C08B37/0021 ,  A61K47/26 ,  C07H3/06

    摘要： The invention relates to an oligosaccharide having a weight average molecular weight (Mw) of less than 3,000 Daltons, wherein said oligosaccharide comprises functional aldehyde groups and has a dimer saccharide content of 2.9 % by weight or less, based on the total weight of the hydrogenated oligosaccharide. The invention also relates to a process for preparing the oligosaccharide, which process comprises the steps of: hydrolysing a polysaccharide so as to reduce its molecular weight, wherein the resulting oligosaccharide comprises functional aldehyde groups, and fractioning the oligosaccharide according to molecular weight, so that the purified fraction has a weight average molecular weight equal to or less than 3,000 Daltons. The procedure of purification is performed by one or more membrane processes, having a cut-off value between 340 and 800 Daltons, which procedure is continued until the content of dimer saccharide in the purified fraction of oligosaccharide has been reduced to 2.9 % by weight or less, based on the total weight of the hydrogenated oligosaccharide.

    摘要翻译： 本发明涉及重均分子量（Mw）小于3,000道尔顿的寡糖，其中所述寡糖包含官能醛基，二聚糖含量为2.9重量％以下，基于氢化物的总重量 寡糖。 本发明还涉及制备寡糖的方法，该方法包括以下步骤：水解多糖以降低其分子量，其中所得寡糖包含官能醛基，并根据分子量对寡糖进行分级，使得 纯化级分的重均分子量等于或小于3,000道尔顿。 纯化的过程通过一个或多个膜过程进行，其截止值在340和800道尔顿之间，该过程继续进行，直到寡糖的纯化级分中的二聚体糖的含量已经降至2.9重量％，或 较少，基于氢化寡糖的总重量。