公开(公告)号：EP2526934B1

公开(公告)日：2015-12-09

申请号：EP12166305.8

申请日：2006-12-28

申请人： Pharmacyclics LLC

发明人： Honingberg, Lee ,  Verner, Erik ,  Pan, Zhengying ,  Mody, Tarak

IPC分类号： A61K31/00 ,  A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61P35/02

CPC分类号： A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described arc irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.