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公开(公告)号：EP3252128A3
公开(公告)日：2018-03-28
申请号：EP17165988.1
申请日：2007-04-02
IPC分类号： C10B53/02 , C10C5/00 , C07D305/14 , A61K36/13 , C10B49/22
摘要： The present invention relates to a thermal extraction method, comprising:
i) preparing a diterpenoid-containing biomass starting material comprising a species of the genus Taxus or Austrotaxus, wherein the biomass is reduced in size to an average diameter of less than about 2 cm in its smallest dimension;
ii) introducing the reduced size biomass starting material into a thermal extraction system comprising a contained vessel, a heat source, and at least one recovery unit;
iii) heating the reduced size biomass starting material to a temperature of from about 250°C to about 650°C; and
iv) collecting a condensed thermal extract comprising:
a) paclitaxel; and
b) 13-acetyl-9-dihydrobaccatin III,
wherein
a) the ratio of the concentration of 13-acetyl-9-dihydrobaccatin III to the concentration of paclitaxel in the condensed thermal extract is approximately 10;
b) the ratio of the concentration of 13-acetyl-9-dihydrobaccatin III in the condensed thermal extract to the concentration of 13-acetyl-9-dihydrobaccatin III in the starting material is at least 10;
c) the residence time of the biomass starting material in the thermal extraction system is less than about 30 seconds; and
d) the thermal extraction method is exclusive of a solvent extraction.摘要翻译： 本发明涉及一种热提取方法，其包括：i）制备含有二萜类物质的生物质起始材料，所述生物质起始物质包含紫杉属或Austrotaxus属物种，其中所述生物质的尺寸减小至平均直径小于约2厘米 其最小的尺寸; ii）将尺寸减小的生物质原料引入包括容器，热源和至少一个回收单元的热提取系统中; iii）将尺寸减小的生物质原料加热至约250℃至约650℃的温度; 和iv）收集浓缩的热提取物，其包含：a）紫杉醇; 和b）13-乙酰-9-二氢巴卡丁III，其中a）浓缩热提取物中13-乙酰基-9-二氢巴卡丁III浓度与紫杉醇浓度之比约为10; b）缩合热提取物中13-乙酰基-9-二氢浆果赤霉素III的浓度与原料中13-乙酰基-9-二氢浆果赤霉素III的浓度之比至少为10; c）生物质原料在热提取系统中的停留时间小于约30秒; 和d）热提取方法不包括溶剂提取。
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公开(公告)号：EP3252128B1
公开(公告)日：2019-01-02
申请号：EP17165988.1
申请日：2007-04-02
IPC分类号： C10B53/02 , C10C5/00 , C07D305/14 , A61K36/13 , C10B49/22
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公开(公告)号：EP3252128A1
公开(公告)日：2017-12-06
申请号：EP17165988.1
申请日：2007-04-02
IPC分类号： C10B53/02 , C10C5/00 , C07D305/14 , A61K36/13 , C10B49/22
摘要： The present invention relates to a thermal extraction method, comprising:
i) preparing a diterpenoid-containing biomass starting material comprising a species of the genus Taxus or Austrotaxus, wherein the biomass is reduced in size to an average diameter of less than about 2 cm in its smallest dimension;
ii) introducing the reduced size biomass starting material into a thermal extraction system comprising a contained vessel, a heat source, and at least one recovery unit;
iii) heating the reduced size biomass starting material to a temperature of from about 250°C to about 650°C; and
iv) collecting a condensed thermal extract comprising:
a) paclitaxel; and
b) 13-acetyl-9-dihydrobaccatin III,
wherein
a) the ratio of the concentration of 13-acetyl-9-dihydrobaccatin III to the concentration of paclitaxel in the condensed thermal extract is approximately 10;
b) the ratio of the concentration of 13-acetyl-9-dihydrobaccatin III in the condensed thermal extract to the concentration of 13-acetyl-9-dihydrobaccatin III in the starting material is at least 10;
c) the residence time of the biomass starting material in the thermal extraction system is less than about 30 seconds; and
d) the thermal extraction method is exclusive of a solvent extraction.
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