公开(公告)号：EP0675895B1

公开(公告)日：1997-07-23

申请号：EP94902836.9

申请日：1993-12-20

申请人： PIERRE FABRE MEDICAMENT

发明人： ROBIN, Jean-Pierre, SERIPHARM Technopole Univers. ,  KISS, Robert ,  IMBERT, Thierry

IPC分类号： C07H17/04 ,  A61K31/70

CPC分类号： C07H17/04

摘要： Compound of the general formula (I) in which R' is a hydrogen atom or a radical R and R is an acyl residue. The invention also concerns a process for the preparation of said compound, the use of said compound as a drug and in the preparation of a drug for treating cancer. A pharmaceutical composition comprising said compound is also disclosed.

公开(公告)号：EP0710240B1

公开(公告)日：1996-12-18

申请号：EP94922935.5

申请日：1994-07-19

申请人： PIERRE FABRE MEDICAMENT

发明人： JACQUESY, Jean-Claude ,  FAHY, Jacques ,  BERRIER, Christian ,  BIGG, Dennis ,  JOUANNETAUD, Marie-Paule ,  ZUNINO, Fabien ,  KRUCZYNSKI, Anna ,  KISS, Robert

IPC分类号： C07D519/04 ,  A61K31/475

CPC分类号： C07D519/04

摘要： Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of said compounds in therapy and their methods of preparation.

摘要翻译： 通式（1）的长春碱和长春瑞滨家族的新型氟化衍生物和这些分子的治疗可接受的盐。 本发明还涉及所述化合物在治疗中的应用及其制备方法。

公开(公告)号：EP0710240A1

公开(公告)日：1996-05-08

申请号：EP94922935.0

申请日：1994-07-19

申请人： PIERRE FABRE MEDICAMENT

发明人： JACQUESY, Jean-Claude ,  FAHY, Jacques ,  BERRIER, Christian ,  BIGG, Dennis ,  JOUANNETAUD, Marie-Paule ,  ZUNINO, Fabien ,  KRUCZYNSKI, Anna ,  KISS, Robert

IPC分类号： A61K31 ,  A61P35 ,  C07D519

CPC分类号： C07D519/04

摘要： Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of said compounds in therapy and their methods of preparation.