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公开(公告)号：EP3375457A1
公开(公告)日：2018-09-19
申请号：EP18170087.3
申请日：2012-11-23
发明人： CHEN, Pu , JAFARI, Mousa , XU, Wen , CHEN, Baoling , PAN, Ran , KARUNARATNE, Nedra
IPC分类号： A61K47/64 , C07K14/00 , A61K47/12 , C07K7/06 , C07K7/08 , C12N15/113 , C12N15/87 , A61K31/713 , A61P35/00 , A61K9/00 , A61K38/00 , A61K9/08 , C07K19/00 , C07K14/47 , C12N15/11
摘要： The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
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公开(公告)号：EP2782926B1
公开(公告)日：2018-07-04
申请号：EP12852395.8
申请日：2012-11-23
发明人： CHEN, Pu , JAFARI, Mousa , XU, Wen , CHEN, Baoling , PAN, Ran , KARUNARATNE, Nedra
IPC分类号： A61K47/64 , A61K31/713 , C12N15/11 , C12N15/87 , A61P35/00 , C07K14/47 , A61K9/00 , A61K9/08
CPC分类号： A61K47/64 , A61K9/0019 , A61K9/08 , A61K31/713 , A61K38/00 , A61K47/6455 , C07K14/4723 , C07K19/00 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/87 , C12N2310/14 , C12N2320/32 , C12N2320/51
摘要： The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
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公开(公告)号：EP3725333A1
公开(公告)日：2020-10-21
申请号：EP20174827.4
申请日：2012-11-23
发明人： CHEN, Pu , JAFARI, Mousa , XU, Wen , CHEN, Baoling , PAN, Ran , KARUNARATNE, Nedra
IPC分类号： A61K47/64 , A61K31/713 , C12N15/11 , C12N15/87 , A61P35/00 , C07K14/00 , C12N15/113 , C07K14/47 , A61K9/00 , A61K9/08 , A61K38/00
摘要： The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
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公开(公告)号：EP3088413B1
公开(公告)日：2019-05-22
申请号：EP14872058.4
申请日：2014-12-18
发明人： CHEN, Pu , CHU, Dafeng , CHEN, Baoling , XU, Wen , PAN, Ran
IPC分类号： C07K14/00 , A61K47/42 , C12N15/113
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5.发明公开PEPTIDE SEQUENCE DESIGN AND USE THEREOF FOR PEPTIDE-MEDIATED SIRNA DELIVERY 有权肽序列设计及其用途肽siRNA介导的矿区使用费
公开(公告)号：EP2782926A1
公开(公告)日：2014-10-01
申请号：EP12852395.8
申请日：2012-11-23
发明人： CHEN, Pu , JAFARI, Mousa , XU, Wen , CHEN, Baoling , PAN, Ran , KARUNARATNE, Nedra
IPC分类号： C07K14/00 , A61K47/12 , C07K7/06 , C07K7/08 , C12N15/113 , C12N15/87 , A61K31/713
CPC分类号： A61K47/64 , A61K9/0019 , A61K9/08 , A61K31/713 , A61K38/00 , A61K47/6455 , C07K14/4723 , C07K19/00 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/87 , C12N2310/14 , C12N2320/32 , C12N2320/51
摘要： The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
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公开(公告)号：EP3375457B1
公开(公告)日：2020-06-24
申请号：EP18170087.3
申请日：2012-11-23
发明人： CHEN, Pu , JAFARI, Mousa , XU, Wen , CHEN, Baoling , PAN, Ran , KARUNARATNE, Nedra
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公开(公告)号：EP3572421A1
公开(公告)日：2019-11-27
申请号：EP19169415.7
申请日：2014-12-18
发明人： CHEN, Pu , CHU, Dafeng , CHEN, Baoling , XU, Wen , PAN, Ran
IPC分类号： C07K14/00 , A61K47/42 , A61P35/00 , C12N15/113
摘要： The present invention relates to a series of peptides, and a peptide-siRNA complex. The peptide and the siRNA are coupled non-covalently. The peptide based complex effectively enhances delivery of siRNA molecules into the cells and release of siRNA in the cell, and improves siRNA mediated gene silencing efficiency of cellular targets. The invention also relates to a pharmaceutical composition comprising the complex, and a use of the complex in the therapy field of gene.
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8.发明公开POLYPEPTIDE AND USE THEREOF AS DELIVERY CARRIER 审中-公开POLYPEPTID UND VERWENDUNG DAVON ALSFREISETZUNGSTRÄGER
公开(公告)号：EP3088413A1
公开(公告)日：2016-11-02
申请号：EP14872058.4
申请日：2014-12-18
发明人： CHEN, Pu , CHU, Dafeng , CHEN, Baoling , XU, Wen , PAN, Ran
CPC分类号： C12N15/113 , A61K9/5169 , A61K31/713 , A61K47/42 , A61K47/64 , C07K14/47 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： The present invention relates to a series of peptides, and a peptide-siRNA complex. The peptide and the siRNA are coupled non-covalently. The peptide based complex effectively enhances delivery of siRNA molecules into the cells and release of siRNA in the cell, and improves siRNA mediated gene silencing efficiency of cellular targets. The invention also relates to a pharmaceutical composition comprising the complex, and a use of the complex in the therapy field of gene.
摘要翻译： 本发明涉及一系列肽和肽-siRNA复合物。 肽和siRNA非共价偶联。 基于肽的复合物有效地增强了siRNA分子进入细胞的递送和siRNA在细胞中的释放，并且改善了siRNA介导的细胞靶标的基因沉默效率。 本发明还涉及包含该复合物的药物组合物和该基因治疗领域中复合物的用途。
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