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公开(公告)号：EP1423400B2
公开(公告)日：2013-05-22
申请号：EP02753671.3
申请日：2002-03-19
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
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公开(公告)号：EP1423400B1
公开(公告)日：2006-08-09
申请号：EP02753671.3
申请日：2002-03-19
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for syntheiszing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
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公开(公告)号：EP1423400A2
公开(公告)日：2004-06-02
申请号：EP02753671.3
申请日：2002-03-19
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for syntheiszing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
摘要翻译： 自然通过反复多样化，选择和扩增来发展生物分子，如蛋白质。 本发明提供了用于基于核酸模板合成，选择，扩增和发展非天然分子的方法，组合物和系统。 核酸模板的序列用于指导非天然分子如非天然聚合物和小分子的合成。 使用这种方法可以制备和筛选这些分子的组合文库。 在选择分子时，其编码核酸模板可被扩增和/或进化以产生本发明的相同分子，从而允许以类似于天然生物聚合物的扩增的方式扩增和产生非天然分子，例如 多核苷酸和蛋白质。
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