专利检索 ap:("Prolexys Pharmaceuticals, Inc." OR "WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH" OR "The Trustees of Columbia University in the City of New York") AND inv:"QI, Longwu" 第 1 页

1.

发明公开
QUINOXALINE DERIVATIVES AS ANTITUMOR AGENTS 有权
标题翻译：喹喔啉抗肿瘤为活动

公开(公告)号：EP1848698A2

公开(公告)日：2007-10-31

申请号：EP06733907.7

申请日：2006-01-25

申请人： Prolexys Pharmaceuticals, Inc. , WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , The Trustees of Columbia University in the City of New York

发明人： BECKLIN, Robert R. , CHEPANOSKE, Cindy Lou , PELTER, John M. , QI, Longwu , ROBBINS, Paul B. , SAHASRABUDHE, Sudhir R. , SELLIAH, Robert , SIMMONS, Keith , STOCKWELL, Brent R. , VENKAT, Raj, Gopal , VON RECHENBERG, Moritz , ZHEN, Eugene

IPC分类号： C07D239/90 , C07D405/12 , C07D409/12 , A61K31/495 , A61P35/00 , G01N33/68 , G01N33/50

CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872

摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3) . The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives, such like the compounds (1).

2.

发明授权
QUINOXALINE DERIVATIVES AS ANTITUMOR AGENTS 有权
标题翻译：喹喔啉抗肿瘤为活动

公开(公告)号：EP1848698B1

公开(公告)日：2013-03-13

申请号：EP06733907.7

申请日：2006-01-25

申请人： Prolexys Pharmaceuticals, Inc. , WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , The Trustees of Columbia University in the City of New York

发明人： BECKLIN, Robert R. , CHEPANOSKE, Cindy Lou , PELTER, John M. , QI, Longwu , ROBBINS, Paul B. , SAHASRABUDHE, Sudhir R. , SELLIAH, Robert , SIMMONS, Keith , STOCKWELL, Brent R. , VENKAT, Raj, Gopal , VON RECHENBERG, Moritz , ZHEN, Eugene

IPC分类号： C07D239/90 , C07D405/12 , C07D409/12 , A61K31/495 , A61P35/00 , G01N33/68 , G01N33/50

CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872

3.

发明公开
3-ARYL-SUBSTITUTED QUINAZOLONES, AND USES THEREOF 审中-公开
标题翻译： 3-芳基 - 取代的quinazolones及其用途

公开(公告)号：EP1999116A2

公开(公告)日：2008-12-10

申请号：EP06848105.0

申请日：2006-12-22

申请人： Prolexys Pharmaceuticals, Inc.

发明人： QI, Longwu , VENKAT, Raj, Gopal , PIERCE, Michael , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert

IPC分类号： C07D239/91

CPC分类号： C07D239/91

摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.