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1.发明公开SUBSTITUTED PURINYL DERIVATIVES WITH IMMUNOMODULATOR AND CHEMOPROTECTIVE ACTIVITY AND USE ALONE OR WITH MEDIUM-CHAIN LENGTH FATTY ACIDS OR GLYCERIDES 审中-公开取代嘌呤基衍生物的免疫调节和化学预防活动，并使用单独的或与OR中链脂肪酸甘油酯
公开(公告)号：EP1784190A1
公开(公告)日：2007-05-16
申请号：EP05779573.4
申请日：2005-09-02
CPC分类号： A61K31/20 , A61K31/23 , A61K31/417 , A61K31/52 , A61K2300/00
摘要： The present invention describes new biological activities of immunomodulating 6-substituted purinyl compounds which make them particularly useful during the treatment of cancer. Collectively, these new biological activities make these purinyl compounds useful chemoprotective agents for the treatment of myelosuppression which is associated with cancer chemotherapy and/or radiotherapy. This chemoprotective activity is in addition to the immunomodulating and subsequent anticancer activity displayed by these compounds, The chemoprotective usefulness of these compounds is further enhanced by the use of medium-chain fatty acids or salts or triglycerides or mono- or diglycerides in combination with the 6-substituted purinyl compounds of this invention.
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