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1.发明公开ALUMINA NANOPARTICLE BIOCONJUGATES AND METHODS OF STIMULATING AN IMMUNE RESPONSE USING SAID BIOCONJUGATES 有权铝纳米颗粒生物缀合物和方法起搏的免疫反应这些生物共轭
公开(公告)号：EP2608811A1
公开(公告)日：2013-07-03
申请号：EP11764011.0
申请日：2011-08-26
申请人： Providence Health System - Oregon , The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University
发明人： HU, Hong-Ming , LI, Haiyan , JIAO, Jun
CPC分类号： A61K47/48238 , A61K45/06 , A61K47/6923 , A61K47/6929
摘要： Disclosed are nanoparticle-autophagosome conjugates capable of stimulating an immune response against a target antigen, wherein the nanoparticle-autophagosome conjugates include autophagosome(s) covalently attached to alumina nanoparticle(s), wherein the autophagosome includes defective ribosomal products (DRiPs) of the target antigen. Also disclosed are immunogenic compositions including these conjugates and/or antigen- presenting cells loaded with these conjugates, and methods of stimulating an immune response against a target antigen by administration of immunogenic compositions including these conjugates and/or antigen-presenting cells loaded with these conjugates.
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2.发明授权ALUMINA NANOPARTICLE BIOCONJUGATES AND METHODS OF STIMULATING AN IMMUNE RESPONSE USING SAID BIOCONJUGATES 有权铝纳米颗粒生物缀合物和方法起搏的免疫反应这些生物共轭
公开(公告)号：EP2608811B1
公开(公告)日：2015-01-28
申请号：EP11764011.0
申请日：2011-08-26
申请人： Providence Health & Services - Oregon , The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University
发明人： HU, Hong-Ming , LI, Haiyan , JIAO, Jun
CPC分类号： A61K47/48238 , A61K45/06 , A61K47/6923 , A61K47/6929
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