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    SPIROCYCLIC MORPHINANS AND THEIR USE
    1.
    发明公开
    SPIROCYCLIC MORPHINANS AND THEIR USE 有权
    螺吗啡及其用途

    公开(公告)号：EP2931726A1

    公开(公告)日：2015-10-21

    申请号：EP13823986.8

    申请日：2013-12-13

    申请人： Purdue Pharma LP

    发明人： GOEHRING, R., Richard ,  TAFESSE, Laykea ,  YOUNGMAN, Mark, A.

    IPC分类号： C07D471/20 ,  A61K31/437 ,  A61P29/00

    CPC分类号： C07D471/10 ,  C07D471/20

    摘要： The application is directed to compounds of Formula (I'-Α), and especially to compounds of Formula (I-A) and pharmaceutically acceptable salts and solvates thereof, wherein R
    1a -R
    5a , Y, Z
    a are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I'-Α), and especially compounds of Formula (I-A), to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.

    BUPRENORPHINE ANALOGS
    2.
    发明公开
    BUPRENORPHINE ANALOGS 有权
    丁丙诺啡类似物

    公开(公告)号：EP2326651A1

    公开(公告)日：2011-06-01

    申请号：EP09789036.2

    申请日：2009-07-30

    申请人： Purdue Pharma LP

    发明人： KYLE, Donald, J. ,  GOEHRING, R., Richard ,  FUNDYTUS, Marian, E.

    IPC分类号： C07D489/12 ,  A61K31/485 ,  A61P25/04

    CPC分类号： C07D489/12 ,  C07D489/02

    摘要： The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula II or Formula III shown below, wherein R
    1 , R
    2 , R
    8 , R
    3 , R
    3a , R
    3b , X, Z and Y are as defined herein., R1 H3CO (I) OCH3 OCH3 (III) Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid and ORLl receptors.

    摘要翻译： 本发明涉及如下所示的式I，式II或式III的丁丙诺啡类似物化合物，其中R 1，R 2，R 8，R 3，R 3a，R 3b，X，Z和Y如本文所定义 （III）本发明的化合物可用于治疗由阿片样物质和ORL1受体的活性调节的疼痛和其他病症。