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公开(公告)号：EP2753606B1
公开(公告)日：2017-07-05
申请号：EP12770217.3
申请日：2012-08-31
申请人： Purdue Pharma LP
发明人： NI, Chiyou , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark
IPC分类号： C07D233/90 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , A61K31/4418 , A61P25/08
CPC分类号： C07D239/42 , A61K31/506 , C07D233/90 , C07D239/34 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04
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公开(公告)号：EP2753606A1
公开(公告)日：2014-07-16
申请号：EP12770217.3
申请日：2012-08-31
申请人： Purdue Pharma LP
发明人： NI, Chiyou , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark
IPC分类号： C07D233/90 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , A61K31/4418 , A61P25/08
CPC分类号： C07D239/42 , A61K31/506 , C07D233/90 , C07D239/34 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04
摘要： The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A
1 , X, A
2 , W
1 , W
2 , W
3 , E, Z, and R
4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.摘要翻译： 本公开提供式（I）的取代的嘧啶化合物及其药学上可接受的盐，前药和溶剂合物，其中A1，X，A2，W1，W2，E，Z和R4如本说明书所述 。 本公开还涉及式（I）的化合物用于治疗对钠通道阻断作出反应的病症。 本公开的化合物特别可用于治疗疼痛。
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公开(公告)号：EP2655330B1
公开(公告)日：2016-02-10
申请号：EP11813366.9
申请日：2011-12-21
申请人： Purdue Pharma LP
发明人： NI, Chiyou , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark , ZHOU, Xiaoming
IPC分类号： C07D213/75 , C07D401/02 , C07D401/12 , C07D401/14 , A61K31/44 , A61K31/4439 , A61P25/00
CPC分类号： C07D213/75 , C07D213/76 , C07D213/81 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/12
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公开(公告)号：EP2964639B1
公开(公告)日：2018-05-02
申请号：EP14710633.0
申请日：2014-03-03
申请人： Purdue Pharma LP
发明人： LOCKMAN, Jeffrey , NI, Chiyou , PARK, Jae Hyun , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark, A.
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/14 , C07D405/12 , C07D239/42 , C07D413/04 , C07D471/08 , C07D487/08 , A61P29/00 , A61K31/506
CPC分类号： C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08
摘要： The present disclosure provides substituted pyrimidine carboxamides of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
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公开(公告)号：EP2593434A1
公开(公告)日：2013-05-22
申请号：EP11755436.0
申请日：2011-07-15
申请人： Purdue Pharma LP
发明人： KYLE, Donald, J. , NI, Chiyou , PARK, Minnie , TAFESSE, Laykea
IPC分类号： C07D213/81 , C07D401/12 , C07D413/12 , A61K31/443 , A61K31/444 , A61K31/4412 , A61K31/4439 , A61P25/00
CPC分类号： C07D213/79 , C07B59/002 , C07D213/56 , C07D213/81 , C07D401/12 , C07D413/12 , C07D413/14
摘要： The invention relates to substituted pyridine compounds of Formula I: (I) or a pharmaceutically acceptable salt, prodrug, or solvate thereof wherein A1, X, A2, R1a, R1b, R1c, G, and z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
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公开(公告)号：EP2964639A1
公开(公告)日：2016-01-13
申请号：EP14710633.0
申请日：2014-03-03
申请人： Purdue Pharma LP
发明人： LOCKMAN, Jeffrey , NI, Chiyou , PARK, Jae Hyun , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark, A.
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/14 , C07D405/12 , C07D239/42 , C07D413/04 , C07D471/08 , C07D487/08 , A61P29/00 , A61K31/506
CPC分类号： C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08
摘要： The present disclosure provides substituted pyrimidine carboxamides of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
摘要翻译： 本公开提供了式（I）的取代的嘧啶甲酰胺及其药学上可接受的盐和溶剂化物，其中A1，X，A2，W1，W2，W3，E，Z和R4如本说明书所述定义。 本公开还涉及式（I）的化合物用于治疗对钠通道阻断作出反应的病症。 本公开的化合物特别可用于治疗疼痛。
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公开(公告)号：EP2655330A1
公开(公告)日：2013-10-30
申请号：EP11813366.9
申请日：2011-12-21
申请人： Purdue Pharma LP
发明人： NI, Chiyou , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark , ZHOU, Xiaoming
IPC分类号： C07D213/75 , C07D401/02 , C07D401/12 , C07D401/14 , A61K31/44 , A61K31/4439 , A61P25/00
CPC分类号： C07D213/75 , C07D213/76 , C07D213/81 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R
1a , R
1b , R
2a , R
2b , R
2c , A
1 , A
2 , and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
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