公开(公告)号：EP2880033A1

公开(公告)日：2015-06-10

申请号：EP13765756.5

申请日：2013-07-29

申请人： Purdue Pharma LP ,  Shionogi & Co., Ltd

发明人： UENO, Tatsuhiko ,  TSUNO, Naoki

IPC分类号： C07D471/08 ,  C07D498/08 ,  A61K31/498 ,  A61P3/00 ,  A61P25/00

CPC分类号： C07D401/14 ,  C07D471/08 ,  C07D498/08

摘要： The disclosure relates to Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein R
1 , R
2 , Q
a , Y
1 , Z, A, B, Q
x , E, G, J, M, U, W, and a are as defined herein, compositions comprising an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxal ine-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound.

摘要翻译： 本公开涉及式（I）的环状脲或内酰胺取代的喹喔啉型哌啶化合物及其药学上可接受的衍生物：其中R1，R2，Qa，Y1，Z，A，B，Qx，E，G， M，U，W和a如本文所定义，包含有效量的环脲或内酰胺取代的喹喔啉型哌啶化合物的组合物，以及治疗或预防诸如疼痛的病症的方法，包括给予 有需要的动物有效量的循环尿素或内酰胺取代的喹喔啉哌啶化合物。

公开(公告)号：EP2147914B1

公开(公告)日：2014-06-04

申请号：EP08751985.6

申请日：2008-04-23

申请人： Shionogi & Co., Ltd.

发明人： TAMURA, Yuusuke ,  SUZUKI, Shinji ,  TADA, Yukio ,  YONEZAWA, Shuji ,  FUJIKOSHI, Chiaki ,  MATSUMOTO, Sae ,  KOORIYAMA, Yuuji ,  UENO, Tatsuhiko

IPC分类号： C07D279/06 ,  A61K31/497 ,  A61K31/54 ,  A61K31/541 ,  A61P25/28 ,  A61P43/00 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

公开(公告)号：EP2147914A1

公开(公告)日：2010-01-27

申请号：EP08751985.6

申请日：2008-04-23

申请人： Shionogi&Co., Ltd.

发明人： TAMURA, Yuusuke ,  SUZUKI, Shinji ,  TADA, Yukio ,  YONEZAWA, Shuji ,  FUJIKOSHI, Chiaki ,  MATSUMOTO, Sae ,  KOORIYAMA, Yuuji ,  UENO, Tatsuhiko

IPC分类号： C07D279/06 ,  A61K31/497 ,  A61K31/54 ,  A61K31/541 ,  A61P25/28 ,  A61P43/00 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I):

wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R 1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R 2a and R 2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R 3a , R 3b , R 3c and R 3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof,
which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R 1为任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R 2a和R 2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R 3a，R 3b，R 3c和R 3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂化物，其可用于治疗由淀粉样蛋白²蛋白质的产生，分泌和/或沉积诱导的疾病。

公开(公告)号：EP2305672A1

公开(公告)日：2011-04-06

申请号：EP09762528.9

申请日：2009-06-11

申请人： Shionogi & Co., Ltd.

发明人： HORI, Akihiro ,  YONEZAWA, Shuji ,  FUJIKOSHI, Chiaki ,  MATSUMOTO, Sae ,  KOORIYAMA, Yuuji ,  UENO, Tatsuhiko ,  KATO, Terukazu

IPC分类号： C07D417/12 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/541 ,  A61P25/28 ,  A61P43/00 ,  C07D417/10 ,  C07D417/14

CPC分类号： C07D417/12 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/10 ,  C07D417/14 ,  C07D487/04

摘要： The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example,. a compound represented by the formula (I):

wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group,
R 1 is optionally substituted lower alkyl or the like,
R 2a and R 2b are each independently hydrogen, optionally substituted lower alkyl or the like,
R 3a and R 3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like,
or a pharmaceutically acceptable salt thereof, or a solvate thereof.

摘要翻译： 提供以下化合物作为治疗由例如淀粉样蛋白²蛋白质的产生，分泌和/或沉积引起的疾病的药剂。 由式（I）表示的化合物：其中，A是任选取代的碳环基或任选取代的杂环基，R 1是任选取代的低级烷基等，R 2a和R 2b各自独立地为氢，任选取代的低级 烷基等，R 3a和R 3c各自独立地为氢，卤素，羟基，任选取代的低级烷基等，或其药学上可接受的盐或其溶剂合物。

公开(公告)号：EP3693373A1

公开(公告)日：2020-08-12

申请号：EP18865221.8

申请日：2018-10-05

申请人： Shionogi & Co., Ltd.

发明人： OKAMOTO, Kazuya ,  UENO, Tatsuhiko ,  HATO, Yoshio ,  HAKOGI, Toshikazu ,  MAJIMA, Shohei

IPC分类号： C07D498/14 ,  C07D213/89 ,  C07D401/12

摘要： The present invention provides industrially suitable processes for preparing intermediates in the production of substituted polycyclic pyridone derivatives having a cap-dependent endonuclease inhibitory activity.
In the process as shown below, wherein each symbol is as defined in the specification, an optically active substituted tricyclic pyridone derivative of the formula (VII) is obtained in high yield and high enantioselectivity by subjecting a compound of the formula (III) or (VI) to intramolecular cyclization with controlling stereochemistry to obtain a compound of the formula (IV) having a removable functional group on an asymmetric carbon, and then removing the functional group thereof.

公开(公告)号：EP2305672B1

公开(公告)日：2019-03-27

申请号：EP09762528.9

申请日：2009-06-11

申请人： Shionogi & Co., Ltd.

发明人： HORI, Akihiro ,  YONEZAWA, Shuji ,  FUJIKOSHI, Chiaki ,  MATSUMOTO, Sae ,  KOORIYAMA, Yuuji ,  UENO, Tatsuhiko ,  KATO, Terukazu

IPC分类号： C07D417/12 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/541 ,  A61P25/28 ,  A61P43/00 ,  C07D417/10 ,  C07D417/14