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1.发明公开METHODS AND COMPOSITIONS FOR EXPANDING, IDENTIFYING, CHARACTERIZING AND ENHANCING POTENCY OF MAMMALIAN-DERIVED GLIAL RESTRICTED PROGENITOR CELLS 审中-公开扩增，鉴定，表征和增强哺乳动物源性限制性前列腺细胞的能力的方法和组合物
公开(公告)号：EP3269803A2
公开(公告)日：2018-01-17
申请号：EP17188092.5
申请日：2010-11-09
申请人： Q Therapeutics, Inc.
CPC分类号： C12N5/0622
摘要： Methods for producing a population of human-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended or undesired cellular phenotypes and/or decreased standard deviation in the cells of the population are provided. Also provided are antibody panels and gene expression profiles to characterize GRPs and a method for its use in characterizing GRP cells. In addition methods for use of these GRP cells to generate astrocytes and/or oligodendrocytes, to re-myelinate neurons and to treat glial cell related and other neurodegenerative diseases or disorders or injuries or damage to the nervous system are provided. A method to manufacture neural cells depleted of A2B5 positive cells is also provided.
摘要翻译： 提供了用于产生具有降低的潜在的非预期或不希望的细胞表型和/或群体细胞中标准偏差减少的人源神经胶质限制性祖细胞（GRP）的方法。 还提供了用于表征GRP的抗体组和基因表达谱以及其用于表征GRP细胞的方法。 此外，还提供了使用这些GRP细胞产生星形胶质细胞和/或少突胶质细胞，重新髓鞘化神经元和治疗神经胶质细胞相关的和其他神经退行性疾病或障碍或神经系统损伤或损伤的方法。 还提供了制造贫化A2B5阳性细胞的神经细胞的方法。
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公开(公告)号：EP3269803A3
公开(公告)日：2018-04-25
申请号：EP17188092.5
申请日：2010-11-09
申请人： Q Therapeutics, Inc.
CPC分类号： C12N5/0622
摘要： Methods for producing a population of human-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended or undesired cellular phenotypes and/or decreased standard deviation in the cells of the population are provided. Also provided are antibody panels and gene expression profiles to characterize GRPs and a method for its use in characterizing GRP cells. In addition methods for use of these GRP cells to generate astrocytes and/or oligodendrocytes, to re-myelinate neurons and to treat glial cell related and other neurodegenerative diseases or disorders or injuries or damage to the nervous system are provided. A method to manufacture neural cells depleted of A2B5 positive cells is also provided.
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