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公开(公告)号：EP0296641A2
公开(公告)日：1988-12-28
申请号：EP88200129.0
申请日：1983-08-12
CPC分类号： C07K5/06139 , C12N9/00 , C12N9/90 , C12N11/18 , C12P35/00 , C12P35/06 , C12P37/00 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A peptide precursor of the ACV (aminoadipyl-cysteinyl-valine) type, in which the valine moiety may be replaced by any readily available amino acid may be converted into a cephalosporin of the type
where R, is H, lower alkyl or functionalized carboxylic group and R 2 is H or lower alkyl, by reacting the precursor with novel cyclase, epimerase and ring expansion enzymes isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three novel enzymes may be immobilized separately or together on a suitable support medium and the conversion may be carried out in a continuous mode.摘要翻译： ACV（氨基己二酰基 - 半胱氨酰 - 缬氨酸）类型的肽前体，其中缬氨酸部分可被任何容易获得的氨基酸替代，可转化为类型
的头孢菌素，其中R 1为H，低级烷基或官能化 羧酸基团，并且R 2是H或低级烷基，通过使前体与从原核生物例如Streptomyces clavuligerus的无细胞提取物分离的新型环化酶，差向异构酶和环扩增酶反应。 三种新型酶可以单独地或一起固定在合适的载体介质上，并且转化可以以连续模式进行。 -
公开(公告)号：EP0295724A3
公开(公告)日：1990-04-18
申请号：EP88200131.6
申请日：1983-08-12
CPC分类号： C07K5/06139 , C12N9/00 , C12N9/90 , C12N11/18 , C12P35/00 , C12P35/06 , C12P37/00 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A peptide precursor of the ACV (aminoadipyl-cysteinyl-valine) type, in which the valine moiety may be replaced by any readily available amino acid may be converted into a cephalosporin of the type
where R 1 is H, lower alkyl or functionalized carboxylic group and R 2 is H or lower alkyl, by reacting the precursor with novel cyclase, epimerase and ring expansion enzymes isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three novel enzymes may be immobilized separately or together on a suitable support medium and the conversion may be carried out in a continuous mode.摘要翻译： ACV（氨基己二酰 - 半胱氨酰 - 缬氨酸）类型的肽前体（其中缬氨酸部分可以被任何容易获得的氨基酸置换）可以转化为其中R1是H，低级烷基或官能化羧基类型的头孢菌素和 R2是H或低级烷基，通过使前体与从原核生物如链霉菌（Streptomyces clavuligerus）的无细胞提取物分离的新型环化酶，差向异构酶和环扩张酶反应。 三种新型酶可以分别或一起固定在合适的载体介质上，并且转化可以以连续模式进行。
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公开(公告)号：EP0296641A3
公开(公告)日：1990-06-20
申请号：EP88200129.0
申请日：1983-08-12
CPC分类号： C07K5/06139 , C12N9/00 , C12N9/90 , C12N11/18 , C12P35/00 , C12P35/06 , C12P37/00 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A peptide precursor of the ACV (aminoadipyl-cysteinyl-valine) type, in which the valine moiety may be replaced by any readily available amino acid may be converted into a cephalosporin of the type
where R, is H, lower alkyl or functionalized carboxylic group and R 2 is H or lower alkyl, by reacting the precursor with novel cyclase, epimerase and ring expansion enzymes isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three novel enzymes may be immobilized separately or together on a suitable support medium and the conversion may be carried out in a continuous mode.摘要翻译： ACV（氨基己二酰 - 半胱氨酰 - 缬氨酸）类型的肽前体（其中缬氨酸部分可以被任何容易获得的氨基酸置换）可以转化为其中R1是H，低级烷基或官能化羧基类型的头孢菌素 R2是H或低级烷基，通过使前体与从原核生物如链霉菌（Streptomyces clavuligerus）的无细胞提取物分离的新型环化酶，差向异构酶和扩环酶反应。 三种新型酶可以分别或一起固定在合适的载体介质上，并且转化可以以连续模式进行。
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公开(公告)号：EP0296642A3
公开(公告)日：1990-04-11
申请号：EP88200130.8
申请日：1983-08-12
CPC分类号： C07K5/06139 , C12N9/00 , C12N9/90 , C12N11/18 , C12P35/00 , C12P35/06 , C12P37/00 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A peptide precursor of the ACV (aminoadipyl-cysteinylvaline) type, in which the valine moiety may be replaced by any readily available amino acid may be converted into a cephalosporin of the type
where R₁ is H, lower alkyl or functionalized carboxylic group and R₂ is H or lower alkyl, by reacting the precursor with novel cyclase, epimerase and ring expansion enzymes isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus . The three novel enzymes may be immobilized separately or together on a suitable support medium and the conversion may be carried out in a continuous mode.摘要翻译： ACV（氨基己二酰基半胱氨酰缬氨酸）类型的肽前体，其中缬氨酸部分可被任何容易获得的氨基酸替代，可转化为类型
的头孢菌素，其中R 1为H，低级烷基或官能化羧基，R 2 通过使前体与从原核生物例如链霉菌（Streptomyces clavuligerus）的无细胞提取物分离的新型环化酶，差向异构酶和环膨化酶反应而形成H或低级烷基。 三种新型酶可以单独地或一起固定在合适的载体介质上，并且转化可以以连续模式进行。 -
公开(公告)号：EP0296642A2
公开(公告)日：1988-12-28
申请号：EP88200130.8
申请日：1983-08-12
CPC分类号： C07K5/06139 , C12N9/00 , C12N9/90 , C12N11/18 , C12P35/00 , C12P35/06 , C12P37/00 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A peptide precursor of the ACV (aminoadipyl-cysteinylvaline) type, in which the valine moiety may be replaced by any readily available amino acid may be converted into a cephalosporin of the type
where R₁ is H, lower alkyl or functionalized carboxylic group and R₂ is H or lower alkyl, by reacting the precursor with novel cyclase, epimerase and ring expansion enzymes isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus . The three novel enzymes may be immobilized separately or together on a suitable support medium and the conversion may be carried out in a continuous mode.摘要翻译： ACV（氨基己二酰 - 半胱胺酰缬氨酸）类型的肽前体（其中缬氨酸部分可以被任何容易得到的氨基酸置换）可以转化为其中R 1是H，低级烷基或官能化羧基并且R 2是类型的头孢菌素 H或低级烷基，通过将前体与从原核生物如链霉菌（Streptomyces clavuligerus）的无细胞提取物分离的新型环化酶，差向异构酶和扩环酶反应。 三种新型酶可以分别或一起固定在合适的载体介质上，并且转化可以以连续模式进行。
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公开(公告)号：EP0295724A2
公开(公告)日：1988-12-21
申请号：EP88200131.6
申请日：1983-08-12
CPC分类号： C07K5/06139 , C12N9/00 , C12N9/90 , C12N11/18 , C12P35/00 , C12P35/06 , C12P37/00 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A peptide precursor of the ACV (aminoadipyl-cysteinyl-valine) type, in which the valine moiety may be replaced by any readily available amino acid may be converted into a cephalosporin of the type
where R 1 is H, lower alkyl or functionalized carboxylic group and R 2 is H or lower alkyl, by reacting the precursor with novel cyclase, epimerase and ring expansion enzymes isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three novel enzymes may be immobilized separately or together on a suitable support medium and the conversion may be carried out in a continuous mode.摘要翻译： ACV（氨基己二酰基 - 半胱氨酰 - 缬氨酸）类型的肽前体，其中缬氨酸部分可被任何容易获得的氨基酸替代，可转化为类型
的头孢菌素，其中R 1为H，低级烷基或官能化 羧酸基团，并且R 2是H或低级烷基，通过使前体与从原核生物例如Streptomyces clavuligerus的无细胞提取物分离的新型环化酶，差向异构酶和环扩增酶反应。 三种新型酶可以单独地或一起固定在合适的载体介质上，并且转化可以以连续模式进行。
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