公开(公告)号：EP3411042A1

公开(公告)日：2018-12-12

申请号：EP17704071.4

申请日：2017-02-06

申请人： Quadram Institute Bioscience

发明人： JUGE, Nathalie ,  MONESTIER, Marie Maguelonne ,  FIELD, Robert Andrew

IPC分类号： A61K31/7012 ,  A61K47/26

CPC分类号： C12Y302/01018 ,  A23L29/06 ,  A23L33/10 ,  A23L33/125 ,  A61K31/7012 ,  A61K38/47 ,  A61K45/06 ,  A61K48/00 ,  C12N9/2402 ,  C12P19/26 ,  Y02A50/481

摘要： The present invention relates to an intramolecular frans-sialidase (IT-sialidase) enzyme from Ruminococcus gnavus and fragments thereof. It also relates to methods of production of the IT- sialidase or its fragments, in addition to uses of the IT-sialidase, its fragments, or compositions comprising the IT-sialidase. One of the uses of the IT-sialidase or its fragments encompassed by the present invention is a method for production of 2,7-anhydro sialic acid derivatives. Further uses of the IT-sialidase enzyme include the therapeutic and prophylactic treatment of infections and respiratory conditions.