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2.发明公开Use of triclosan in the treatment of diseases of the gastrointestinal tract 失效治疗TRICLOSAN治疗胃肠疾病的疾病的应用
公开(公告)号：EP0455475A3
公开(公告)日：1992-02-26
申请号：EP91303929.3
申请日：1991-05-01
IPC分类号： A61K31/085
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/5026 , A61K9/5047 , A61K31/085
摘要： The use of triclosan for the preparation of medicaments for the treatment of gastrointestinal disorders associated with Helicobacter pylori infections is disclosed. The medicaments may be in the form of powders, granules, spheroids or liquids, or in unit dosage form as capsules or tablets containing 1 to 100mg, preferably 10 to 60mg, of triclosan. The medicaments may also be in gastric sustained release form as raft forming tablets or liquids, optionally to be co-administered with a solid pharmaceutically acceptable carboxylic acid or acid salt, or as muco-adherent-coated granules or spheroids.
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公开(公告)号：EP0193400A3
公开(公告)日：1989-04-19
申请号：EP86301394.2
申请日：1986-02-26
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A61K31/415 , A61K31/34 , A61K2300/00
摘要： Pharmaceutical compositions comprising mixtures of a histamine H 2 -receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of a histamine H 2 -receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers. In a modification in the mixtures the sodium polyacrylate may be replaced wholly or in part by potassium or ammonium polyacrylate.
摘要翻译： 已发现包含特定范围比例的组胺H 2 - 受体拮抗剂如西咪替丁或雷尼替丁与聚丙烯酸钠的混合物的药物组合物在用于抗溃疡或粘膜保护剂的体内测试模型中显示协同效应。 描述了包含比例范围的组胺H 2 - 受体拮抗剂例如西咪替丁或雷尼替丁与聚丙烯酸钠的混合物的药物组合物用于治疗胃炎或胃 - 十二指肠溃疡。 在混合物中的改进中，聚丙烯酸钠可以全部或部分地被钾或聚丙烯酸铵替代。
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公开(公告)号：EP0169684A2
公开(公告)日：1986-01-29
申请号：EP85304907.0
申请日：1985-07-10
IPC分类号： A61K31/195 , A61K31/78 , A61K33/00
CPC分类号： A61K31/78 , A61K33/00 , A61K31/195 , A61K2300/00
摘要： Pharmaceutical compositions comprising mixtures of proglumide and polyacrylic acid or their sodium salts in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of proglumide and polyacrylic acid or their sodium salts in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers.
摘要翻译： 已发现包含特定范围比例的丙谷胺和聚丙烯酸或其钠盐的混合物的药物组合物在抗溃疡或粘膜保护剂的体内测试模型中显示出协同效应。 描述了包含比例范围的丙谷胺和聚丙烯酸或其钠盐的混合物的药物组合物用于治疗胃炎或胃十二指肠溃疡。
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5.发明授权
公开(公告)号：EP0455475B1
公开(公告)日：1995-07-05
申请号：EP91303929.3
申请日：1991-05-01
IPC分类号： A61K31/085
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/5026 , A61K9/5047 , A61K31/085
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公开(公告)号：EP0136006B1
公开(公告)日：1991-01-09
申请号：EP84305124.4
申请日：1984-07-27
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A61K31/225 , A61K2300/00
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公开(公告)号：EP0136006A2
公开(公告)日：1985-04-03
申请号：EP84305124.4
申请日：1984-07-27
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A61K31/225 , A61K2300/00
摘要： Pharmaceutical compositions comprising mixtures of sodium polyacrylate and carbenoxolone sodium in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of sodium polyacrylate and carbenoxolone in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers.
摘要翻译： 已发现包含特定范围比例的聚丙烯酸钠和生胃酮钠的混合物的药物组合物在抗溃疡或粘膜保护剂的体内试验模型中显示出协同效应。 描述了包含一定比例范围的聚丙烯酸钠和生胃酮的混合物的药物组合物用于治疗胃炎或胃十二指肠溃疡。
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公开(公告)号：EP0193400B1
公开(公告)日：1991-10-23
申请号：EP86301394.2
申请日：1986-02-26
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A61K31/415 , A61K31/34 , A61K2300/00
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公开(公告)号：EP0193400A2
公开(公告)日：1986-09-03
申请号：EP86301394.2
申请日：1986-02-26
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A61K31/415 , A61K31/34 , A61K2300/00
摘要： Pharmaceutical compositions comprising mixtures of a histamine H 2 -receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of a histamine H 2 -receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers. In a modification in the mixtures the sodium polyacrylate may be replaced wholly or in part by potassium or ammonium polyacrylate.
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10.发明公开Use of triclosan in the treatment of diseases of the gastrointestinal tract 失效Verwendung von Triclosan zur Behandlung von Krankheiten des Gastrointestinaltraktes。
公开(公告)号：EP0455475A2
公开(公告)日：1991-11-06
申请号：EP91303929.3
申请日：1991-05-01
IPC分类号： A61K31/085
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/5026 , A61K9/5047 , A61K31/085
摘要： The use of triclosan for the preparation of medicaments for the treatment of gastrointestinal disorders associated with Helicobacter pylori infections is disclosed. The medicaments may be in the form of powders, granules, spheroids or liquids, or in unit dosage form as capsules or tablets containing 1 to 100mg, preferably 10 to 60mg, of triclosan. The medicaments may also be in gastric sustained release form as raft forming tablets or liquids, optionally to be co-administered with a solid pharmaceutically acceptable carboxylic acid or acid salt, or as muco-adherent-coated granules or spheroids.
摘要翻译： 公开了使用三氯生制备用于治疗与幽门螺杆菌感染相关的胃肠道疾病的药物。 药物可以是粉末，颗粒，球状体或液体的形式，或以单位剂型形式，作为含有1至100mg，优选10至60mg三氯生的胶囊或片剂。 药物也可以是片剂形式的片剂或液体的胃缓释形式，任选地与固体药学上可接受的羧酸或酸盐共同施用，或作为粘膜粘附的颗粒或球体。
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