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    Therapeutic system for controlled release of drugs
    3.
    发明公开
    Therapeutic system for controlled release of drugs 无效
    治疗系统治疗仪Wirkstoffabgabe。

    公开(公告)号：EP0250374A1

    公开(公告)日：1987-12-23

    申请号：EP87830223.1

    申请日：1987-06-15

    申请人： RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. ,  CONSIGLIO NAZIONALE DELLE RICERCHE

    发明人： La Manna, Aldo ,  Colombo, Paolo ,  Gazzaniga, Andrea ,  Santus, Giancarlo ,  Conte, Ubaldo ,  Sangalli, Maria Edvige

    IPC分类号： A61K9/52 ,  A61K9/22

    CPC分类号： A61K9/1652 ,  A61K9/1635 ,  A61K9/5026

    摘要： A new modular delivery system is described, which is able to release the vehicled active ingredient at controlled rate and for a predetermined period of time.
    The new system is characterized by:


    1. Dosage units obtained by compression comprising natural and/or synthetic, hydrophilic, biocompatible polymers, capable to swell on contact with water or aqueous fluids thus providing a swelling pressure, containing a therapeutically active dose of drug or fractions thereof,
    2. A polymeric barrier coated on said units, which will break because of units volume increase after their contact with water, and controlling the fluids entrance within the system and, therefore, the core swelling.
    The active ingredient release is almost complete, and it may occur according to zero-order kinetics without insoluble residues of appreciable extent.
    A process for preparing said system is also described.

    摘要翻译： 描述了一种新的模块化递送系统，其能够以受控的速率和预定的时间段释放车辆的活性成分。 新系统的特征在于：1.通过压缩获得的由天然和/或合成的，亲水的，生物相容的聚合物获得的剂量单元，其能够在与水或含水流体接触时膨胀，从而提供溶胀压力，其含有治疗活性剂量的药物或 2.聚合物屏障涂覆在所述单元上，由于在与水接触之后单位体积增加而破裂，并且控制流体在体系内的入口，并因此控制芯膨胀。 活性成分释放几乎完成，根据零级动力学可能会发生明显程度的不溶性残留物。 还描述了用于制备所述系统的方法。