专利检索 ap:("REGENERON PHARMACEUTICALS, INC.") AND inv:"SHANKER, Gopi, Y." 第 1 页

1.

发明公开
METHODS OF ISOLATION OF ACTIVE COMPOUNDS AND ACTIVATED TARGETS 审中-公开
标题翻译：隔离方法活性化合物和资本金目标

公开(公告)号：EP1563298A2

公开(公告)日：2005-08-17

申请号：EP03742008.0

申请日：2003-06-17

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： MURPHY, Andrew, J. , SHANKER, Gopi, Y. , YANCOPOULOS, George, D.

IPC分类号： G01N33/53 , C12Q1/68 , C12N15/00

CPC分类号： C40B30/04 , C07K14/685 , C07K14/705 , C07K14/70535 , C07K16/44 , C07K2317/622 , C07K2319/00 , C07K2319/30 , G01N33/6845 , G01N33/6857

摘要： Methods for identifying a compound capable of modulating activity of a target active domain, by generating a first fusion protein having an anchor component and a variable component, generating a second fusion protein having a docking domain and an active domain, wherein the anchor component and the docking domain are binding partners, then contacting the fusion proteins under conditions in which the anchor component and the docking domain bind, and determining the activity of the target domain.