公开(公告)号：EP0743958B1

公开(公告)日：2003-07-23

申请号：EP95910893.7

申请日：1995-02-06

申请人： RESEARCH DEVELOPMENT FOUNDATION

发明人： ROSENBLUM, Michael G. ,  DONATO, Nicholas J.

IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K19/00 ,  A61K48/00 ,  A61K51/00 ,  A61K121/00 ,  A61K47/48

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/6898 ,  A61K48/00 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/77 ,  C12N15/87

摘要： The present invention provides a non-viral vector, comprising a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. Also, provided is a method of introducing genetic material inside a specific cell comprising the administration of the non-viral vector to a human, wherein said non-viral vector comprises a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. In addition, there is provided a method of delivering a cytotoxic moiety to a cell comprising the administration of the non-viral vector to a human.

公开(公告)号：EP0743958A1

公开(公告)日：1996-11-27

申请号：EP95910893.0

申请日：1995-02-06

申请人： RESEARCH DEVELOPMENT FOUNDATION

发明人： ROSENBLUM, Michael G. ,  DONATO, Nicholas J.

IPC分类号： C12N15 ,  A61K38 ,  A61K47 ,  A61K48 ,  A61P35 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N9 ,  C12P21

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/6898 ,  A61K48/00 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/77 ,  C12N15/87

摘要： The present invention provides a non-viral vector, comprising a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. Also, provided is a method of introducing genetic material inside a specific cell comprising the administration of the non-viral vector to a human, wherein said non-viral vector comprises a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. In addition, there is provided a method of delivering a cytotoxic moiety to a cell comprising the administration of the non-viral vector to a human.