利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.009 秒)

    NEW STEROIDS
    1.
    发明授权
    NEW STEROIDS 失效
    新类固醇

    公开(公告)号：EP0675897B1

    公开(公告)日：1997-06-18

    申请号：EP94903944.0

    申请日：1993-12-24

    申请人： RHONE-POULENC RORER LIMITED

    发明人： ASHTON, Michael, John Rhone-Poulenc Rorer Ltd. ,  KARLSSON, Sven, Jan-Anders ,  VACHER, Bernard, Yvon, Jack ,  WITHNALL, Michael, Thomas

    IPC分类号： C07J71/00 ,  A61K31/56

    CPC分类号： C07J71/0031 ,  C07J3/005 ,  C07J5/0092

    摘要： Steroids of formula (I) where -^_-^_-^_-^_ is independently at each of the 1,2-, 4,5- and 6,7-positions, a single or double bond; R1 is a straight- or branched-chain C1-4 alkyl or C2-4 alkenyl; R2 is hydrogen or methyl; R3 is C1-7 alkyl, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl or -CH2R where R is halo, hydroxy, C1-5 alkoxy or C1-10 alkanoyloxy; R4 is hydrogen, halo, hydroxy, keto or C1-3 alkoxy when -^_-^_-^_-^_ at the 6,7-position forms a single bond, or hydrogen, halo or C1-3 alkoxy when -^_-^_-^_-^_ at the 6,7-position forms a double bond; R5 is hydrogen or halo; R6 is hydrogen when -^_-^_-^_-^_ at the 1,2-position forms a single bond or hydrogen or chloro when -^_-^_-^_-^_ at the 1,2-position forms a double bond; and n is 0-2; and racemic mixtures and diastereoisomers thereof, processes for their preparation, pharmaceutical compositions containing them, and methods for their use, especially as antiinflammatories.