公开(公告)号：EP0200436A3

公开(公告)日：1989-01-18

申请号：EP86302933.6

申请日：1986-04-18

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Szántay, Csaba ,  Incze, Mária ,  Szombathelye, Zsolt ,  Sóti, Ferenc ,  Balogh, Zsuzsanna ,  Kárpati, Egon ,  Kiss, Béla ,  Csomor, Katsalin ,  Laszlovsky, István ,  Lapis, Erzsébet ,  Szporny, László ,  Forgács, Lilla ,  Kuthi, Csaba

IPC分类号： C07D471/14 ,  A61K31/44

CPC分类号： C07D471/14

摘要： The invention relates to new racemic and optically active 12b-substituted 1-hydroxymethyl-octahydroindolo[2,3- alquinolizine derivatives of formula (I)
wherein
R' and R 2 are the same or different and represent hydrogen, halogen, nitro, amino, hydroxyl, alkyl having from 1 to 6 carbon atoms or alkoxy having from 1 to 6 carbon atoms; R 3 and R 5 are the same or different and represent hydrogen, alkyl having from 1 to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety; R 4 is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety; R 6 is hydrogen or alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, and the isomers and acid addition salts thereof. The compounds of the invention are valuable as intermediates in the preparation of pharmaceutically active compounds and are pharmaceutically active themselves.

公开(公告)号：EP0200436A2

公开(公告)日：1986-11-05

申请号：EP86302933.6

申请日：1986-04-18

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Szántay, Csaba ,  Incze, Mária ,  Szombathelye, Zsolt ,  Sóti, Ferenc ,  Balogh, Zsuzsanna ,  Kárpati, Egon ,  Kiss, Béla ,  Csomor, Katsalin ,  Laszlovsky, István ,  Lapis, Erzsébet ,  Szporny, László ,  Forgács, Lilla ,  Kuthi, Csaba

IPC分类号： C07D471/14 ,  A61K31/44

CPC分类号： C07D471/14

摘要： The invention relates to new racemic and optically active 12b-substituted 1-hydroxymethyl-octahydroindolo[2,3- alquinolizine derivatives of formula (I)
wherein

R' and R 2 are the same or different and represent hydrogen, halogen, nitro, amino, hydroxyl, alkyl having from 1 to 6 carbon atoms or alkoxy having from 1 to 6 carbon atoms;
R 3 and R 5 are the same or different and represent hydrogen, alkyl having from 1 to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety;
R 4 is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety;
R 6 is hydrogen or alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, and the isomers and acid addition salts thereof.
The compounds of the invention are valuable as intermediates in the preparation of pharmaceutically active compounds and are pharmaceutically active themselves.

摘要翻译： 本发明涉及式（I）的新的外消旋和光学活性的12b-取代的1-羟甲基 - 八氢吲哚并〔2,3-a〕喹嗪衍生物，