公开(公告)号：EP1495767A1

公开(公告)日：2005-01-12

申请号：EP03746173.8

申请日：2003-04-15

申请人： Riken ,  Cell-Medicine, Inc.

发明人： OHNO, Tadao ,  UCHIMURA, Eiji c/o RIKEN, TSUKUBA INSTITUTE ,  HUANG, Lan c/o RIKEN, TSUKUBA INSTITUTE ,  KUANG, Ming c/o RIKEN, TSUKUBA INSTITUTE

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  A61K2039/55583

摘要： An immunoadjuvant which can efficiently exhibit potent adjuvant activity and avoid conditions undesirable for living bodies, and comprises precipitates formed by coacervation of (a) a soluble protein (provided that a soluble protein contained in tuberculin is excluded), and (b) a mucopolysaccharide, and further comprises (c) a soluble protein contained in tuberculin wherein said (c) is coprecipitated with the precipitates.

摘要翻译： （a）可溶性蛋白质（只要不包含结核菌素中所含的可溶性蛋白质）和（b）粘多糖的凝聚形成的沉淀物，可以有效地显示出强烈的佐剂活性并避免对活体所不期望的条件的免疫佐剂， （c）包含在结核菌素中的可溶性蛋白质，其中所述（c）与所述沉淀物共沉淀。

公开(公告)号：EP1495767B1

公开(公告)日：2006-10-25

申请号：EP03746173.8

申请日：2003-04-15

申请人： RIKEN ,  Cell-Medicine, Inc.

发明人： OHNO, Tadao ,  UCHIMURA, Eiji c/o RIKEN, TSUKUBA INSTITUTE ,  HUANG, Lan c/o RIKEN, TSUKUBA INSTITUTE ,  KUANG, Ming c/o RIKEN, TSUKUBA INSTITUTE

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  A61K2039/55583

摘要： An immunoadjuvant capable of efficiently exerting a potent adjuvant activity while avoiding conditions undesirable for a living body which contains: (a) a soluble protein (excluding a soluble protein contained in tuberculin); (b) a precipitate due to coacervation of a mucopolysaccharide; and (c) a soluble protein contained in tuberculin which is coprecipitated with the above precipitate.