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    Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
    3.
    发明公开
    Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes 失效
    喹啉酮[4,5-c]喹啉酮和1H-咪唑并[4,5-c]嘧啶-4-胺的合成。

    公开(公告)号：EP0310950A1

    公开(公告)日：1989-04-12

    申请号：EP88116137.6

    申请日：1984-11-16

    申请人： RIKER LABORATORIES, INC.

    发明人： Gerster, John F.

    IPC分类号： C07D215/42

    CPC分类号： C07D471/04 ,  C07D215/42

    摘要： Compounds of the types (I) and (II) are disclosed,
    wherein each R₅ is independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms and halogen, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R₅ substituents together contain no more than 6 carbon atoms; R₆ is selected from the group consisting of hydroxyalkyl of one to about six carbon atoms and cyclohexyl­methyl; and R₇ is selected from the group consisting of alkyl of one to about four carbon atoms and hydrogen.
    These compounds may be used as intermediates for the synthesis of 1H-imidazo[4,5-c]quinoline derivatives.

    摘要翻译： 公开了类型（I）和（II）的化合物，其中每个R 5独立地选自1至约4个碳原子的烷基，1至约4个碳原子的烷氧基和卤素，n 是从0到2的整数，条件是如果n是2，那么所说的R 5取代基一起含有不多于6个碳原子; R6选自1至约6个碳原子的羟烷基和环己基甲基; 并且R 7选自1至约4个碳原子的烷基和氢。 这些化合物可以用作合成1H-咪唑并[4,5-c]喹啉衍生物的中间体。

    1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines
    5.
    发明公开
    1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines 失效
    1H-咪唑并（4,5c）喹啉和1H-咪唑并（4,5-c）嘧啶-4-胺。

    公开(公告)号：EP0145340A2

    公开(公告)日：1985-06-19

    申请号：EP84307974.0

    申请日：1984-11-16

    申请人： RIKER LABORATORIES, INC.

    发明人： Gerster, John F.

    IPC分类号： C07D471/04 ,  A61K31/47 ,  C07D215/42

    CPC分类号： C07D471/04 ,  C07D215/42

    摘要： @ Classes of substituted 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines are disclosed as bronchodilator agents and antiviral agents, respectively. Pharmacological methods of using the compounds as bronchodilators and antiviral agents, pharmaceutical compositions containing the compounds and synthetic intermediates for preparing the compounds are also described.

    摘要翻译： 分别公开了取代的1H-咪唑并[4,5-c]喹啉和1H-咪唑并[4,5-c]喹啉-4-胺的类别作为支气管扩张剂和抗病毒剂。 还描述了使用化合物作为支气管扩张剂和抗病毒剂的药理学方法，含有化合物的药物组合物和用于制备化合物的合成中间体。