公开(公告)号：EP0286364A3

公开(公告)日：1990-08-01

申请号：EP88303037.1

申请日：1988-04-06

申请人： RIKER LABORATORIES, INC.

发明人： Scherrer, Robert A., c/o Riker Labs. Inc., ,  Rustad, Mark A., c/o Riker Labs. Inc.,

IPC分类号： C07C233/75 ,  C07C235/46 ,  C07C255/49 ,  C07C255/57 ,  C07D257/04 ,  A61K31/165 ,  A61K31/41

CPC分类号： C07D257/04 ,  C07C255/00

摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.

公开(公告)号：EP0286364B1

公开(公告)日：1994-07-13

申请号：EP88303037.1

申请日：1988-04-06

申请人： RIKER LABORATORIES, INC.

发明人： Scherrer, Robert A., c/o Riker Labs. Inc., ,  Rustad, Mark A., c/o Riker Labs. Inc.,

IPC分类号： C07C233/75 ,  C07C235/46 ,  C07C255/49 ,  C07C255/57 ,  C07D257/04 ,  A61K31/165 ,  A61K31/41

CPC分类号： C07D257/04 ,  C07C255/00

公开(公告)号：EP0286364A2

公开(公告)日：1988-10-12

申请号：EP88303037.1

申请日：1988-04-06

申请人： RIKER LABORATORIES, INC.

发明人： Scherrer, Robert A., c/o Riker Labs. Inc., ,  Rustad, Mark A., c/o Riker Labs. Inc.,

IPC分类号： C07C233/75 ,  C07C235/46 ,  C07C255/49 ,  C07C255/57 ,  C07D257/04 ,  A61K31/165 ,  A61K31/41

CPC分类号： C07D257/04 ,  C07C255/00

摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.

摘要翻译： 作为氨基甲酰基或酰氨基取代4位的2,6-二叔丁基酚的新型化合物，该氨基甲酰基或酰氨基被包含酸性取代基的基团取代，可用作白三烯生物合成抑制剂和抗过敏药 代理商。 还公开了使用这些化合物和合成中间体制备这些化合物的药理学方法。