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    Transdermal estrogen/progestin dosage unit, and fertility control kit comprising said dosage unit.
    1.
    发明公开
    Transdermal estrogen/progestin dosage unit, and fertility control kit comprising said dosage unit. 失效
    蜕皮激素/孕激素 - 爱因斯顿，系统和Verfahren。

    公开(公告)号：EP0275716A1

    公开(公告)日：1988-07-27

    申请号：EP87311508.3

    申请日：1987-12-29

    申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

    发明人： Chien, Yie W., ,  Chien, Te-Yen, ,  Huang, Yih-Chain,

    IPC分类号： A61L15/16 ,  A61K31/565

    CPC分类号： A61K9/7061 ,  A61K9/7092 ,  A61K31/565 ,  A61K31/567

    摘要： Transdermal estrogen progestin absorption dosage units have been developed which comprise a backing layer, an adjoining polymer layer is an adhesive layer in which at least minimum effective dose of an estrogen is dissolved or microdispersed. Adhered to the polymer layer is an adhesive layer in which is dissolved and or microdispersed at least minimum doses of progestin. Presently preferred is use of the natural estrogen, 17-beta-estradiol, or ethinyl estradiol or combinations thereof and of the progestin, norethindrone or norgestimate or combinations thereof. The units have biologically acceptable adhesive and polymer layers. The adhesive layer can have dispersed one or more skin permeation enhancing agents. A separating layer can optionally be used in making the dosage units, which separate space the adhesive and polymer layers, which permits estrogen transmission from the polymer layer during treatment. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control and estrogen replacement therapy using the novel dosage units. Also. the invention provides a fertility control system for fertility control using the novel dosage units.

    摘要翻译： 已经开发了经皮雌激素/孕激素吸收剂量单位，其包含背衬层，相邻的聚合物层是其中至少最小有效剂量的雌激素溶解或微分散的粘合剂层。 粘附到聚合物层上的粘合剂层是其中溶解和/或微分散至少最小剂量的孕激素的粘合剂层。 目前优选使用天然雌激素，17-β-雌二醇或乙炔雌二醇或其组合以及孕激素，炔诺酮或诺孕酯或其组合。 这些单元具有生物可接受的粘合剂和聚合物层。 粘合剂层可以具有分散的一种或多种皮肤渗透增强剂。 分离层可以可选地用于制备剂量单位，其分离空间粘合剂和聚合物层，其允许在治疗期间从聚合物层传递雌激素。 提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。 本发明还提供使用新型剂量单位的生育调节和雌激素替代疗法的方法。 此外，本发明提供了使用新型剂量单位的育性控制的育性控制系统。