公开(公告)号：EP4286518A1

公开(公告)日：2023-12-06

申请号：EP22742867.9

申请日：2022-01-21

申请人： RZNOMICS INC.

发明人： LEE, Seong-Wook ,  CHO, Eun Yi ,  KIM, Tae Young ,  PARK, Hye Rim

IPC分类号： C12N15/113 ,  C07K16/28 ,  A61K31/7088 ,  A61P35/00

摘要： The present disclosure relates to a cancer-specific trans-splicing ribozyme and a use thereof. The trans-splicing ribozyme does not act on normal tissues but is specifically expressed in cancer tissues, and thus the safety thereof is high and the expression efficiency thereof is excellent at the post-transcription level, and one or more target genes are connected to the 3' exon of the ribozyme so that a cancer therapeutic gene and an immune checkpoint inhibitor are expressed together when applied in vivo, and thus the present disclosure can be effectively used in cancer treatment.