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公开(公告)号：EP2285951B1
公开(公告)日：2018-07-04
申请号：EP09754337.5
申请日：2009-05-26
发明人： KADOURI, Avinoam , BAR-ILAN, Avihay , MELAMED, Eldad , OFFEN, Daniel , SADAN, Ofer , BAHAT-STROMZA, Merav
CPC分类号： A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
摘要： The present invention relates to an isolated human cell comprising a cell being non-genetically manipulated, and characterized by: a) expressing tyrosine hydroxylase, nestin and H-NF and b) secreting brain-derived neurotrophic factor (BDNF), and b) not secreting nerve growth factor (NGF) wherein a basal secretion of said BDNF is at least five times greater than a basal secretion of said BDNF in a mesenchymal stem cell.
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公开(公告)号：EP3514229A1
公开(公告)日：2019-07-24
申请号：EP19155870.9
申请日：2009-05-26
发明人： KADOURI, Avinoam , BAR-ILAN, Avihay , MELAMED, Eldad , OFFEN, Daniel , SADAN, Ofer , BAHAT-STROMZA, Merav
IPC分类号： C12N5/079 , C12N5/0775 , A61K35/28 , A61P25/28
摘要： The present invention relates to an isolated human cell comprising a cell being non-genetically manipulated, and characterized by: a) expressing tyrosine hydroxylase, nestin and H-NF and b) secreting brain-derived neurotrophic factor (BDNF), and b) not secreting nerve growth factor (NGF) wherein a basal secretion of said BDNF is at least five times greater than a basal secretion of said BDNF in a mesenchymal stem cell.
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3.发明公开MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CNS DISEASES 有权MESENCHYMALE STAMMZELLEN ZUR BEHANDLUNG VON ERKRANKUNGEN DES ZENTRALNERVENSYSTEMS
公开(公告)号：EP2285951A1
公开(公告)日：2011-02-23
申请号：EP09754337.5
申请日：2009-05-26
发明人： KADOURI, Avinoam , BAR-ILAN, Avihay , MELAMED, Eldad , OFFEN, Daniel , SADAN, Ofer , BAHAT-STROMZA, Merav
CPC分类号： A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
摘要： The present invention relates to an isolated human cell comprising a cell being non-genetically manipulated, and characterized by: a) expressing tyrosine hydroxylase, nestin and H-NF and b) secreting brain-derived neurotrophic factor (BDNF), and b) not secreting nerve growth factor (NGF) wherein a basal secretion of said BDNF is at least five times greater than a basal secretion of said BDNF in a mesenchymal stem cell.
摘要翻译： 本发明涉及包含非遗传操作细胞的分离的人细胞，其特征在于：a）表达酪氨酸羟化酶，巢蛋白和H-NF，以及b）分泌脑源性神经营养因子（BDNF），和b）不 分泌神经生长因子（NGF），其中所述BDNF的基础分泌比间充质干细胞中所述BDNF的基础分泌大至少五倍。
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