公开(公告)号：EP2096164B1

公开(公告)日：2016-05-11

申请号：EP07739894.9

申请日：2007-03-27

申请人： National University Corporation Kagawa University ,  Rare Sugar Production Technical Research Laboratories, LLC ,  Matsutani Chemical Industry Co., Ltd.

发明人： IZUMORI, Ken ,  MORIMOTO, Kenji ,  TAKATA, Goro ,  TOKUDA, Masaaki ,  TSUJISAKA, Yoshio ,  TAKESHITA, Kei ,  TSUSAKI, Keiji ,  OKUMA, Kazuhiro

IPC分类号： C12N1/20 ,  A61K8/60 ,  C12N9/04 ,  C12P7/18 ,  C12P19/02 ,  C12R1/01

CPC分类号： C12R1/01 ,  A61K8/60 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/0006 ,  C12P19/02

公开(公告)号：EP2096164A1

公开(公告)日：2009-09-02

申请号：EP07739894.9

申请日：2007-03-27

申请人： National University Corporation Kagawa University ,  Rare Sugar Production Technical Research Laboratories, LLC ,  Fushimi Pharmaceutical Company, Limited ,  Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo ,  Matsutani Chemical Industry Co., Ltd.

发明人： IZUMORI, Ken ,  MORIMOTO, Kenji ,  TAKATA, Goro ,  TOKUDA, Masaaki ,  TSUJISAKA, Yoshio ,  TAKESHITA, Kei ,  TSUSAKI, Keiji ,  OKUMA, Kazuhiro

IPC分类号： C12N1/20 ,  A61K8/60 ,  C12N9/04 ,  C12P7/18 ,  C12P19/02

CPC分类号： C12R1/01 ,  A61K8/60 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/0006 ,  C12P19/02

摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.
Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.

摘要翻译： 问题：在生产脱氧多元醇脱氢酶的能力提供了一个微生物与。 用于解决方法：一种微生物，属于肠杆菌属的与在位置C2和C3象核糖醇或L-艾杜糖醇的以产生用于相同的结构的多元醇脱氧脱氢酶的能力。 肠杆菌属（保藏号NITE P-271）的细菌细胞IK7。 一种生产脱氧酮糖包括允许培养含有由本发明的微生物的培养或允许脱氧多元醇脱氢酶与在位置C2和C3为含有相同的结构的脱氧多羟基化合物的溶液中反应而获得的脱氧多元醇脱氢酶方法 确实核糖醇或L-艾杜糖醇的氧化脱氧多羟基化合物，以产生相应脱氧酮糖，然后收集所述脱氧酮糖。 脱氧多羟基化合物是1-脱氧-D-蒜糖醇，而相应的脱氧酮糖是1-脱氧-L-阿洛酮糖。 否则，脱氧多羟基化合物是L-rhamnitol，而相应的脱氧酮糖是1-脱氧-L-果糖。

公开(公告)号：EP1864669B1

公开(公告)日：2018-06-27

申请号：EP06729659.0

申请日：2006-03-22

申请人： Rare Sugar Production Technical Research Laboratories, LLC ,  Matsutani Chemical Industry Co., Ltd.

发明人： TOKUDA, Masaaki ,  MORIMOTO, Kenji ,  MATSUO, Tatsuhiro ,  IZUMORI, Ken ,  TAKEKAWA, Kaoru

IPC分类号： A61K31/7004 ,  A23K20/163 ,  A23K50/40 ,  A23L27/30 ,  A23L33/10 ,  A61P3/10

CPC分类号： A23K50/40 ,  A23K20/163 ,  A23L27/30 ,  A23L33/10 ,  A61K31/7004

摘要： A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

公开(公告)号：EP2103625B1

公开(公告)日：2014-05-07

申请号：EP07739605.9

申请日：2007-03-26

申请人： National University Corporation Kagawa University ,  Rare Sugar Production Technical Research Laboratories, LLC ,  Matsutani Chemical Industry Co., Ltd.

发明人： IZUMORI, Ken ,  MORIMOTO, Kenji ,  TAKATA, Goro ,  TOKUDA, Masaaki ,  TSUJISAKA, Yoshio ,  TAKESHITA, Kei ,  TSUSAKI, Keiji ,  OKUMA, Kazuhiro

IPC分类号： C07K14/195 ,  C12N1/20 ,  C12N9/90 ,  C12P19/24

CPC分类号： C12N9/90 ,  C12P19/24 ,  C12R1/01

公开(公告)号：EP2103625A1

公开(公告)日：2009-09-23

申请号：EP07739605.9

申请日：2007-03-26

申请人： National University Corporation Kagawa University ,  Rare Sugar Production Technical Research Laboratories, LLC ,  Fushimi Pharmaceutical Company, Limited ,  Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo ,  Matsutani Chemical Industry Co., Ltd.

发明人： IZUMORI, Ken ,  MORIMOTO, Kenji ,  TAKATA, Goro ,  TOKUDA, Masaaki ,  TSUJISAKA, Yoshio ,  TAKESHITA, Kei ,  TSUSAKI, Keiji ,  OKUMA, Kazuhiro

IPC分类号： C07K14/195 ,  C12N1/20 ,  C12N9/90 ,  C12P19/24

CPC分类号： C12N9/90 ,  C12P19/24 ,  C12R1/01

摘要： Object: To provide a thermostable L-ribose isomerase.
Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45°C, optimal pH of pH 9. 0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45°C during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.

摘要翻译： 目的：提供热稳定的L-核糖异构酶。 解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH为9.0（甘氨酸 - NaOH缓冲液）的最佳pH，以及稳定的物理化学性质，例如在pH 9.0的热处理期间高达45℃的温度稳定性为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。 醛糖和酮糖之间的转化方法，其包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸龙胆菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇，使醛糖异构化，产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-糖精，D-托洛糖，D-甘露糖，L-阿洛糖和L-古洛糖。

公开(公告)号：EP1860195B1

公开(公告)日：2018-01-03

申请号：EP06715211.6

申请日：2006-03-03

申请人： National University Corporation Kagawa University ,  MATSUTANI CHEMICAL INDUSTRY CO., LTD.

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  TAKADA, Goro ,  MORIMOTO, Kenji

IPC分类号： C12P19/02 ,  C12P19/24 ,  C12R1/38 ,  C07H3/02

CPC分类号： C12P19/02 ,  C12P19/24

摘要： Disclosed is a process for producing a crystalline sugar comprising D-psicose and D-allose. Also disclosed is a process for producing the sugar. A complex crystalline sugar comprising D-psicose and D-allose. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.